Mifepristone followed by home administration of buccal misoprostol for medical abortion up to 70 days of amenorrhoea in a general practice in Curaçao.

Abstract

OBJECTIVE:

To evaluate the efficacy and safety of home administration of buccal misoprostol after mifepristone for medical abortion up to 70 days' gestation in a general practice in Curaçao, where induced abortion is severely restricted by law.

METHODS:

In a prospective study 330 women received 200 mg mifepristone and were instructed to take four tablets (800 μg) of misoprostol via the buccal route 24-36 h later, at home. One week later, follow-up took place.

RESULTS:

The outcome could be evaluated in 307 of the 330 women. The efficacy of the mifepristone-buccal misoprostol procedure was 97.7% (300/307). In seven women vacuum aspirations for continuing pregnancy or incomplete abortion following treatment were required. Success rates at 64-70 days' gestation were the same as for gestations of less than 64 days duration. The main adverse effects were nausea and diarrhoea.

CONCLUSION:

Home administration of buccal misoprostol 24-36 h after mifepristone is a safe and effective method of medical abortion up to 70 days. It could be applied in a general practice in Curaçao, where induced abortion is legally restricted.

• Authors: Adriana A Boersma, Betty Meyboom-de Jong, Gunilla Kleiverda
• Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception (Eur J Contracept Reprod Health Care) Vol. 16 Issue 2 Pg. 61-6 (Apr 2011) ISSN: 1473-0782 [Electronic] England
• PMID: 21303309 (Publication Type: Journal Article)

Chemical References

• Abortifacient Agents, Nonsteroidal
• Abortifacient Agents, Steroidal
• Misoprostol
• Mifepristone

Topics

• Abortifacient Agents, Nonsteroidal (administration & dosage)
• Abortifacient Agents, Steroidal (administration & dosage)
• Abortion, Induced (methods)
• Administration, Buccal
• Adult
• Ambulatory Care Facilities
• Amenorrhea (chemically induced)
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Humans
• Mifepristone (administration & dosage)
• Misoprostol (administration & dosage)
• Netherlands Antilles
• Pregnancy
• Prospective Studies
• Self Administration (methods)
• Treatment Outcome
• Young Adult