Enhanced protection against Heligmosomoides polygyrus in IL-2 receptor β-chain overexpressed transgenic mice with intestinal mastocytosis.

Abstract

IL-2 receptor β-chain overexpressed transgenic (Tg2Rβ) mice lack NK cells, but the development of other lymphocyte subsets and macrophages remained apparently intact. These mice also exhibit intestinal mastocytosis. Helminth infection induces various immune responses, such as mast cells, goblet cells, eosinophils and IgE, mediated by Th2 cytokines. IL-4 is also important in the regulation of resistance and susceptibility to Heligmosomoides polygyrus infection. However, there are contradictory results about the relation between resistance to H. polygyrus and intestinal mastocytosis. The present study showed that Tg2Rβ mice suppressed worm fecundity with mastocytosis without an increase of the levels of goblet cells, eosinophils and IgE compared with control mice. These results clearly indicated that mast cells have the ability for to protect against H. polygyrus infection. However, additional studies are required to evaluate protective effector mechanisms against H. polygyrus.

• Authors: Masahiro Morimoto, Kyoko Utsumiya
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 73 Issue 6 Pg. 849-51 (Jun 2011) ISSN: 1347-7439 [Electronic] Japan
• PMID: 21301182 (Publication Type: Journal Article)

Chemical References

• Interleukin-2 Receptor beta Subunit

Topics

• Animals
• Cell Count
• Feces (parasitology)
• Female
• Interleukin-2 Receptor beta Subunit (genetics, immunology)
• Intestinal Diseases, Parasitic (immunology)
• Male
• Mastocytosis (immunology, parasitology)
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• Nematospiroides dubius (immunology)
• Parasite Egg Count
• Strongylida Infections (immunology, parasitology)