Abstract |
We investigated PfCRT 76T mutation in severe and non-severe malaria in Southern Mali. One hundred and ninety three severe malaria cases were each matched against two non-severe malaria cases. Patients with G6PD deficiency and any known hemoglobin abnormality were excluded. PfCRT 76T was present in 60.8% (n=386) non-severe malaria cases and in 77.2% (n=193) severe malaria cases (p<0.0001). In children 5 years or younger, these proportions were 62.9% (n=294) vs. 73.5% (n=147), respectively (p<0.01). PfCRT 76T was therefore associated with malaria severity in this setting of Mali.
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Authors | Mamadou Wélé, Abdoulaye A Djimdé, Aldiouma Guindo, Abdoul H Beavogui, Isaac Z Traoré, Aboubacar Sadou, Dackouo Blaise, Dapa A Diallo, Thomas E Wellems, Ogobara K Doumbo |
Journal | Acta tropica
(Acta Trop)
Vol. 119
Issue 1
Pg. 11-3
(Jul 2011)
ISSN: 1873-6254 [Electronic] Netherlands |
PMID | 21300016
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier B.V. All rights reserved. |
Chemical References |
- DNA, Protozoan
- Membrane Transport Proteins
- PfCRT protein, Plasmodium falciparum
- Protozoan Proteins
- Chloroquine
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Topics |
- Alleles
- Case-Control Studies
- Child
- Child, Preschool
- Chloroquine
(therapeutic use)
- DNA, Protozoan
(analysis, genetics)
- Drug Resistance
- Female
- Humans
- Infant
- Malaria, Falciparum
(drug therapy, epidemiology, parasitology)
- Male
- Mali
(epidemiology)
- Membrane Transport Proteins
(genetics)
- Mutation
- Plasmodium falciparum
(genetics, parasitology)
- Prevalence
- Protozoan Proteins
(genetics)
- Severity of Illness Index
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