Abstract | INTRODUCTION: The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula has not been validated in patients with cancer. The present investigation was undertaken in order to study how well estimated glomerular filtration rate (eGFR) using the new CKD-EPI equation correlates with measured GFR (mGFR) by (51)chrome ethylene diamine tetraacetic acid ((51)Cr-EDTA) clearance in a group of patients with cancer not known as having cancer. MATERIAL AND METHODS: We investigated 185 patients with cancer who were referred for isotope measurement of GFR with (51)Cr-EDTA before initiating chemotherapy treatment. The agreement between CKD-EPI and (51)Cr-EDTA was assessed using a Bland-Altman plot. Test performance was analysed in a contingency table and bias, precision and the percentage of estimates within 30% of the mGFR (P30) were assessed. RESULTS: Bland-Altman plot analysis showed a limit of agreement in the range from -25.59 to 27.92 ml/min./1.73 m(2). This formula was therefore not interchangeable with (51)Cr-EDTA, as the above differences are of clinical importance. Bias was low: 1.16 ml/min./1.73 m(2); P30 was high: 89.73%; and precision was 13.37 ml/min./1.73 m(2). As a screening test, the CKD-EPI had a high specificity of 98% (95% confidence interval (CI): 96 to 100%) and a high negative predictive value 97% (95% CI: 95 to 100%). The accuracy of the validation test was 96% (95% CI: 93 to 99%). CONCLUSION: The CKD-EPI may be used as a screening tool for CKD in the general population, but cannot replace isotope tests when a high GFR measurement accuracy is needed.
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Authors | Belén Redal-Baigorri, Knud Heine Stokholm, Knud Rasmussen, Nina Jeppesen |
Journal | Danish medical bulletin
(Dan Med Bull)
Vol. 58
Issue 2
Pg. A4236
(Feb 2011)
ISSN: 1603-9629 [Electronic] Denmark |
PMID | 21299923
(Publication Type: Journal Article, Validation Study)
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Chemical References |
- Chelating Agents
- Edetic Acid
- Creatinine
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Topics |
- Chelating Agents
(administration & dosage, metabolism)
- Confidence Intervals
- Creatinine
(metabolism)
- Edetic Acid
(administration & dosage, metabolism)
- Female
- Glomerular Filtration Rate
- Health Status Indicators
- Humans
- Kidney
(pathology)
- Kidney Failure, Chronic
(diagnosis, epidemiology, etiology, pathology)
- Male
- Middle Aged
- Neoplasms
(complications)
- Retrospective Studies
- Sensitivity and Specificity
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