Antitumor effects of 3-[p-(N,N-bis-(2'-chloroethyl)amino)-phenyl]-L- alanine conjugated with human immunoglobulin (K18).

Abstract

K18 (3-[p-(N,N-bis(2'-chloroethyl)amino)- phenyl]-L-alanine conjugated with human immunoglobulin) is a newly developed antitumor agent. LD50 values of K18 in animals were quite high, suggesting its low acute toxicity. This drug showed anti-tumorigenicity not only on an experimental animal tumor (Walker 256), but also on a human tumor transplantable into nude mice (RCC-13). A distribution study clarified the unique properties of K18 to accumulate and remain in the tumor site with a high rate.

• Authors: M Yoshimura, K Niimura, M Fujii, K Matsunaga, Y Oguchi, T Fujii, S Muto, T Furusho, C Yoshikumi
• Journal: In vivo (Athens, Greece) (In Vivo) 1990 Mar-Apr Vol. 4 Issue 2 Pg. 131-5 ISSN: 0258-851X [Print] Greece
• PMID: 2129803 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Immunoglobulins
• Melphalan

Topics

• Animals
• Carcinoma 256, Walker (drug therapy)
• Dogs
• Humans
• Immunoglobulins (administration & dosage)
• Kidney Neoplasms (drug therapy)
• Melphalan (administration & dosage, therapeutic use, toxicity)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred ICR
• Mice, Nude
• Rats
• Rats, Inbred Strains
• Transplantation, Heterologous