Abstract |
Synovial fluid (SF) from rheumatoid arthritis (RA) patients were tested for their ability to inhibit the proliferative responses of normal peripheral blood mononuclear cells ( PBM) to mitogens and interleukin-2 (IL-2). SF significantly inhibited the responses to concanavalin A (CON A) and phytohaemagglutinin (PHA), but significantly enhanced the responses to IL-2. Similarly, SF mononuclear cells (SFM) were hyporesponsive to CON A and PHA compared with autologous PBM, but hyper-responsive to IL-2. It is concluded that an IL-2 inhibitor in RA SF is unlikely to be the cause of SFM hyporesponsiveness to mitogens.
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Authors | A P Hollander, C J Elson |
Journal | Autoimmunity
(Autoimmunity)
Vol. 5
Issue 4
Pg. 237-45
( 1990)
ISSN: 0891-6934 [Print] England |
PMID | 2129757
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Interleukin-2
- Phytohemagglutinins
- Concanavalin A
|
Topics |
- Arthritis, Rheumatoid
(immunology)
- Concanavalin A
(pharmacology)
- Humans
- Interleukin-2
(antagonists & inhibitors, pharmacology)
- Leukocytes, Mononuclear
(immunology)
- Phytohemagglutinins
(pharmacology)
- Synovial Fluid
(cytology, immunology)
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