[Visfatin in obese patients, relation with cardiovascular risk factors, a cross sectional study].

Abstract

BACKGROUND AND OBJECTIVE:

Obesity and insulin resistance are associated with cardiovascular risk factors. The aim of the present study was to explore the relation of visfatin with insulin resistance, cardiovascular risk factors and anthropometry in obese patients without comorbidities.

PATIENTS AND METHOD:

A population of 270 obese patients was analyzed in a prospective way. In all patients we performed a biochemical analysis (lipid profile, insulin, HOMA and visfatina), and a nutritional evaluation (dietary intake, conventional anthropometry and bioimpedance).

RESULTS:

Patients were divided in two groups by median visfatin value (8,32 ng/ml), group I (patients with the low values, average value 7,11 (0,7) ng/ml) and group II (patients with the high values, average value 13,5 (10,1) ng/ml). Patients in the group I had higher weight, body mass index, waist circumference, and waist to hip ratio than patients in group II. Patients in group I had lower LDL-cholesterol and C reactive protein than patients in group II. Correlation analysis showed a positive correlation between visfatin levels and LDL cholesterol (r=0.194; p<0.05) and C reactive protein (r=0.266; p<0.05) and a negative corelation with weight (r=-0.162; p<0.05). In the logistic analysis with age-, sex- and dietary intake- adjusted basal visfatin concentration as a dependent variable, the next variables remained in the model; weight with an odds ratio (OR) 0,97 (IC95% 0,95-0,99), LDL cholesterol 1,012(1,010-1.023) and C reactive protein 1,15 (1.03-1.3).

CONCLUSION:

LDL cholesterol and c reactive protein levels are positively correlated with visfatin levels. Weight is negatively correlated with visfatin levels, in an independent way and adjusted by age, sex and dietary intake.

• Authors: Daniel A de Luis, María Ballesteros, Enrique Ruiz, Carmen Muñoz, Angeles Penacho, Pedro Iglesias, Antonio López Guzmán, Cristina Abreu, Alfonso Maldonado, Manuel Delgado, Lucía San Martín, Victor Puigdevall, Enrique Romero, Manuel González Sagrado, Olatz Izaola, Rosa Conde, Mar Cordero y Rocio Aller, Grupo de Nutrición, Sociedad Castellano Leonesa de Endocrinología, diabetes y nutrición
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 137 Issue 5 Pg. 199-203 (Jul 23 2011) ISSN: 1578-8989 [Electronic] Spain
• Vernacular Title: Visfatina en pacientes obesos, relación con factores de riesgo cardiovascular, un estudio tranversal.
• PMID: 21296365 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright © 2010 Elsevier España, S.L. All rights reserved.

Chemical References

• Biomarkers
• Blood Glucose
• Glycated Hemoglobin A
• Lipids
• C-Reactive Protein
• Nicotinamide Phosphoribosyltransferase

Topics

• Adult
• Anthropometry
• Biomarkers
• Blood Glucose (analysis)
• Body Weight
• C-Reactive Protein (analysis)
• Cardiovascular Diseases (epidemiology)
• Cross-Sectional Studies
• Diet Records
• Female
• Glycated Hemoglobin (analysis)
• Humans
• Insulin Resistance
• Intra-Abdominal Fat (metabolism)
• Lipids (blood)
• Male
• Middle Aged
• Nicotinamide Phosphoribosyltransferase (blood)
• Obesity (blood, epidemiology)
• Prospective Studies
• Risk Factors
• Spain (epidemiology)