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Vitamin D inadequacy is associated with low-energy distal radius fractures: a case-control study.

AbstractINTRODUCTION:
Vitamin D inadequacy is associated with hip fractures, but the relationship has not been explored for distal radius fractures.
AIMS:
To compare serum 25-hydroxyvitamin D (s-25(OH)D) status in low-energy distal radius fracture patients and a group of matched controls, and examine whether observed differences in s-25(OH)D between patients and controls would remain after adjusting for bone mineral density (BMD), body mass index (BMI), and smoking history.
METHODS:
A total of 575 female and 72 male low-energy distal radius fracture patients (50-90 years) and 534 female and 52 male matched controls were included. The primary measure was levels of vitamin D. Secondary measures were BMD assessed by dual energy X-ray absorptiometry, BMI and smoking history.
RESULTS:
Mean s-25(OH)D was 66.5nmol/L in female patients and 78.7nmol/L in controls (p<0.001). The corresponding figures in men were 64.5 and 77.0nmol/L (p=0.017). In adjusted conditional logistic regression analyzes, s-25(OH)D <50nmol/L (OR=2.32, 95% CI: 1.47-3.64, p<0.001), and 50-75 (OR=1.70, 95% CI: 1.17-2.47, p=0.005) were associated with distal radius fractures in women. s-25(OH)D <50nmol/L (OR=6.27, 95% CI: 1.17-33.66, p=0.032) was associated with distal radius fractures in men.
CONCLUSIONS:
Vitamin D inadequacy is associated with low-energy distal radius fractures in both women and men. Differences in vitamin D levels are independent of BMD, BMI or smoking history.
AuthorsJannike Oyen, Ellen Margrete Apalset, Clara Gram Gjesdal, Christina Brudvik, Stein Atle Lie, Leiv M Hove
JournalBone (Bone) Vol. 48 Issue 5 Pg. 1140-5 (May 01 2011) ISSN: 1873-2763 [Electronic] United States
PMID21295169 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Inc. All rights reserved.
Chemical References
  • Vitamin D
  • 25-hydroxyvitamin D
Topics
  • Aged
  • Bone Density (physiology)
  • Case-Control Studies
  • Demography
  • Female
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Radius Fractures (blood, complications, physiopathology)
  • Risk Factors
  • Vitamin D (analogs & derivatives, blood)
  • Vitamin D Deficiency (blood, complications, physiopathology)

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