Abstract | INTRODUCTION: AIMS: To compare serum 25-hydroxyvitamin D (s-25(OH)D) status in low-energy distal radius fracture patients and a group of matched controls, and examine whether observed differences in s-25(OH)D between patients and controls would remain after adjusting for bone mineral density (BMD), body mass index (BMI), and smoking history. METHODS: A total of 575 female and 72 male low-energy distal radius fracture patients (50-90 years) and 534 female and 52 male matched controls were included. The primary measure was levels of vitamin D. Secondary measures were BMD assessed by dual energy X-ray absorptiometry, BMI and smoking history. RESULTS: Mean s-25(OH)D was 66.5nmol/L in female patients and 78.7nmol/L in controls (p<0.001). The corresponding figures in men were 64.5 and 77.0nmol/L (p=0.017). In adjusted conditional logistic regression analyzes, s-25(OH)D <50nmol/L (OR=2.32, 95% CI: 1.47-3.64, p<0.001), and 50-75 (OR=1.70, 95% CI: 1.17-2.47, p=0.005) were associated with distal radius fractures in women. s-25(OH)D <50nmol/L (OR=6.27, 95% CI: 1.17-33.66, p=0.032) was associated with distal radius fractures in men. CONCLUSIONS:
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Authors | Jannike Oyen, Ellen Margrete Apalset, Clara Gram Gjesdal, Christina Brudvik, Stein Atle Lie, Leiv M Hove |
Journal | Bone
(Bone)
Vol. 48
Issue 5
Pg. 1140-5
(May 01 2011)
ISSN: 1873-2763 [Electronic] United States |
PMID | 21295169
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Vitamin D
- 25-hydroxyvitamin D
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Topics |
- Aged
- Bone Density
(physiology)
- Case-Control Studies
- Demography
- Female
- Humans
- Male
- Middle Aged
- Odds Ratio
- Radius Fractures
(blood, complications, physiopathology)
- Risk Factors
- Vitamin D
(analogs & derivatives, blood)
- Vitamin D Deficiency
(blood, complications, physiopathology)
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