Aripiprazole for the treatment of irritability associated with autism.

Abstract

INTRODUCTION:

Irritability (including tantrums, aggression and moodiness) is often associated with autistic disorder. Children with autism are frequently prescribed atypical antipsychotic medications for these behaviors. Although multiple agents have been found to be effective, the safety and tolerability of each antipsychotic may be the determining factor in its selection.

AREAS COVERED:

The pharmacokinetics, pharmacodynamics, safety and efficacy data on aripiprazole for the treatment of irritability associated with autism are discussed. Knowledge of the mechanism of action, advantages and disadvantages relative to other atypical antipsychotics, and an appreciation of the efficacy of aripiprazole when used to treat irritability in autism is also explored in this paper.

EXPERT OPINION:

Aripiprazole may have a more favorable side-effect profile than another commonly prescribed medication, risperidone, because of its unique mechanism of action. It seems to be effective in treating irritability associated with autism, but more research is needed.

• Authors: Cristan Ann Farmer, Michael G Aman
• Journal: Expert opinion on pharmacotherapy (Expert Opin Pharmacother) Vol. 12 Issue 4 Pg. 635-40 (Mar 2011) ISSN: 1744-7666 [Electronic] England
• PMID: 21294670 (Publication Type: Comparative Study, Journal Article, Review)

Chemical References

• Antipsychotic Agents
• Piperazines
• Quinolones
• Aripiprazole
• Risperidone

Topics

• Antipsychotic Agents (adverse effects, pharmacokinetics, therapeutic use)
• Aripiprazole
• Autistic Disorder (drug therapy)
• Humans
• Irritable Mood (drug effects)
• Piperazines (adverse effects, pharmacokinetics, therapeutic use)
• Quinolones (adverse effects, pharmacokinetics, therapeutic use)
• Risperidone (adverse effects, therapeutic use)