Abstract |
In the present study the therapeutic effect and potential toxicity of the novel "Sequential" boron neutron capture therapy (Seq-BNCT) for the treatment of oral cancer was evaluated in the hamster cheek pouch model at the RA-3 Nuclear Reactor. Two groups of animals were treated with "Sequential" BNCT, i.e., BNCT mediated by boronophenylalanine (BPA) followed by BNCT mediated by sodium decahydrodecaborate (GB-10) either 24 h (Seq-24h-BNCT) or 48 h (Seq-48h-BNCT) later. In an additional group of animals, BPA and GB-10 were administered concomitantly [(BPA + GB-10)-BNCT]. The single-application BNCT was to the same total physical tumor dose as the "Sequential" BNCT treatments. At 28 days post-treatment, Seq-24h-BNCT and Seq-48h-BNCT induced, respectively, overall tumor responses of 95 ± 2% and 91 ± 3%, with no statistically significant differences between protocols. Overall response for the single treatment with (BPA + GB-10)-BNCT was 75 ± 5%, significantly lower than for Seq-BNCT. Both Seq-BNCT protocols and (BPA + GB-10)-BNCT induced reversible mucositis in the dose-limiting precancerous tissue around treated tumors, reaching Grade 3/4 mucositis in 47 ± 12% and 60 ± 22% of the animals, respectively. No normal tissue toxicity was associated with tumor response for any of the protocols. "Sequential" BNCT enhanced tumor response without an increase in mucositis in dose-limiting precancerous tissue.
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Authors | Ana J Molinari, Emiliano C C Pozzi, Andrea Monti Hughes, Elisa M Heber, Marcela A Garabalino, Silvia I Thorp, Marcelo Miller, Maria E Itoiz, Romina F Aromando, David W Nigg, Jorge Quintana, Gustavo A Santa Cruz, Verónica A Trivillin, Amanda E Schwint |
Journal | Radiation research
(Radiat Res)
Vol. 175
Issue 4
Pg. 463-72
(Apr 2011)
ISSN: 1938-5404 [Electronic] United States |
PMID | 21294607
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | © 2011 by Radiation Research Society |
Topics |
- Animals
- Boron Neutron Capture Therapy
(adverse effects, methods)
- Cheek
- Cricetinae
- Dose Fractionation, Radiation
- Dose-Response Relationship, Radiation
- Mesocricetus
- Mouth Neoplasms
(pathology, radiotherapy)
- Mucositis
(etiology, pathology, prevention & control)
- Radiation Injuries
(etiology, pathology, prevention & control)
- Radiotherapy Dosage
- Treatment Outcome
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