Immunocytochemical evidence of SV 40-related T antigen in two human brain tumours of ependymal origin.

Abstract

A series of thirty-time human brain tumours has been screened for the presence or absence of SV 40-related T antigen by the direct and indirect immunoperoxidase techniques. Two tumours (an ependymoma and a choroid plexus papilloma) of ependymal origin revealed markedly positive nuclear staining for T antigen both in in vivo and in vitro. The possible viral etiology of these human brain tumours is discussed in relation to recent human papovavirus isolates.

• Authors: K Tabuchi, W M Kirsch, J J Van Buskirk
• Journal: Acta neurochirurgica (Acta Neurochir (Wien)) Vol. 43 Issue 3-4 Pg. 239-49 ( 1978) ISSN: 0001-6268 [Print] Austria
• PMID: 212932 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Viral

Topics

• Animals
• Antigens, Viral (analysis)
• Cerebral Ventricle Neoplasms (metabolism, microbiology)
• Choroid Plexus
• Complement Fixation Tests
• Cricetinae (immunology)
• Ependymoma (metabolism)
• Humans
• Immunoenzyme Techniques
• Simian virus 40 (immunology)