Abstract | AIMS: To determine whether short-term strict glycaemic control could restore incretin secretion in type 2 diabetic patients. The factors associated with incretin levels were also investigated. METHODS: A meal tolerance test (MTT) was performed in eighteen poorly controlled (pDM) and fifteen well controlled (wDM) diabetic patients. Fourteen patients in the pDM group underwent follow-up MTT after strict glycaemic control. The secretions of intact glucagon-like peptide-1 (iGLP-1) and total glucose-dependent insulinotropic polypeptide (tGIP) during MTT were calculated by total and incremental area under the curve (TAUC and IAUC) values. RESULTS: Posttreatment HbA1c level was significantly improved in the pDM group (11.2±0.9 to 7.9±0.9%). However, the secretion of incretin hormones was not increased in the posttreatment pDM group (TAUCiGLP-1, 3612±587 to 2916±405 pmol/L min; TAUCtGIP, 9417±1099 to 8338±903 pmol/L min). IAUCiGLP-1 was negatively correlated (r=-0.446, P=0.011) and independently associated (β=-137.2, P=0.027) with insulin resistance assessed by homeostasis model assessment. CONCLUSIONS:
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Authors | Seung-Hwan Lee, Ji-Hyun Kim, Jeong-Ah Shin, Eun Sook Kim, Jae-Hyoung Cho, Seung-Hyun Ko, Kun-Ho Yoon, Yu-Bae Ahn |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 92
Issue 1
Pg. 74-81
(Apr 2011)
ISSN: 1872-8227 [Electronic] Ireland |
PMID | 21292338
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Blood Glucose
- Hypoglycemic Agents
- Incretins
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Topics |
- Adult
- Aged
- Blood Glucose
(drug effects)
- Diabetes Mellitus, Type 2
(blood, drug therapy, metabolism)
- Female
- Humans
- Hyperglycemia
(blood, drug therapy, metabolism)
- Hypoglycemic Agents
(therapeutic use)
- Incretins
(metabolism)
- Male
- Middle Aged
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