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Incretin secretion is not restored by short-term strict glycaemic control in Korean hyperglycaemic patients with type 2 diabetes.

AbstractAIMS:
To determine whether short-term strict glycaemic control could restore incretin secretion in type 2 diabetic patients. The factors associated with incretin levels were also investigated.
METHODS:
A meal tolerance test (MTT) was performed in eighteen poorly controlled (pDM) and fifteen well controlled (wDM) diabetic patients. Fourteen patients in the pDM group underwent follow-up MTT after strict glycaemic control. The secretions of intact glucagon-like peptide-1 (iGLP-1) and total glucose-dependent insulinotropic polypeptide (tGIP) during MTT were calculated by total and incremental area under the curve (TAUC and IAUC) values.
RESULTS:
Posttreatment HbA1c level was significantly improved in the pDM group (11.2±0.9 to 7.9±0.9%). However, the secretion of incretin hormones was not increased in the posttreatment pDM group (TAUCiGLP-1, 3612±587 to 2916±405 pmol/L min; TAUCtGIP, 9417±1099 to 8338±903 pmol/L min). IAUCiGLP-1 was negatively correlated (r=-0.446, P=0.011) and independently associated (β=-137.2, P=0.027) with insulin resistance assessed by homeostasis model assessment.
CONCLUSIONS:
Incretin secretion is not restored by short-term strict glycaemic control. Decreased incretin secretion seems to develop early in the course of type 2 diabetes with increasing insulin resistance, but not to be influenced by glycaemic status.
AuthorsSeung-Hwan Lee, Ji-Hyun Kim, Jeong-Ah Shin, Eun Sook Kim, Jae-Hyoung Cho, Seung-Hyun Ko, Kun-Ho Yoon, Yu-Bae Ahn
JournalDiabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 92 Issue 1 Pg. 74-81 (Apr 2011) ISSN: 1872-8227 [Electronic] Ireland
PMID21292338 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Chemical References
  • Blood Glucose
  • Hypoglycemic Agents
  • Incretins
Topics
  • Adult
  • Aged
  • Blood Glucose (drug effects)
  • Diabetes Mellitus, Type 2 (blood, drug therapy, metabolism)
  • Female
  • Humans
  • Hyperglycemia (blood, drug therapy, metabolism)
  • Hypoglycemic Agents (therapeutic use)
  • Incretins (metabolism)
  • Male
  • Middle Aged

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