[The immunomodulating properties of a diphtheria bacterial vaccine in in vitro experiments].

Abstract

In this investigation lymphocytes sensitized with Corynebacterium diphtheriae antigens obtained from carriers and convalescents were used. The new diphtheria bacterial vaccine Codivac, in contrast to other comparable preparations (diphtheria toxoid, staphylococcal toxoid, staphylococcal vaccine, levamisole), was found to produce a more direct effect by modulating the levels of T-lymphocytes, depending on their initial levels in the patient. Codivac, together with other preparations, can be used for the study of the problems of immunostimulation and immunocorrective therapy.

• Authors: S M Polkova, E A Shmeleva
• Journal: Zhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) Issue 12 Pg. 62-6 (Dec 1990) ISSN: 0372-9311 [Print] Russia (Federation)
• Vernacular Title: Immunomoduliruiushchie svoĭstva difteriĭnoĭ bakterial'noĭ vaktsiny v opytakh in vitro.
• PMID: 2129148 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adjuvants, Immunologic
• Antigens, Bacterial
• Codivac
• Diphtheria Toxoid
• Staphylococcal Toxoid
• Staphylococcal Vaccines
• Levamisole

Topics

• Adjuvants, Immunologic
• Adolescent
• Adult
• Antigens, Bacterial (immunology)
• Cells, Cultured (drug effects, immunology)
• Corynebacterium diphtheriae (immunology)
• Diphtheria Toxoid (immunology, pharmacology)
• Drug Evaluation, Preclinical
• Humans
• Levamisole (pharmacology)
• Middle Aged
• Staphylococcal Toxoid (pharmacology)
• Staphylococcal Vaccines (pharmacology)
• T-Lymphocytes (drug effects, immunology)