Three novel members of angucycline group from Streptomyces sp. N05WA963.

Abstract

Three novel members of angucycline family named N05WA963A (1), B (2) and D (4), together with a new anthracycline named N05WA963C (3) were isolated from the culture broth of Streptomyces sp. N05WA963. The structures were elucidated on the basis of comprehensive spectral data analysis. All four compounds have shown antiproliferative effects on a panel of cancer cell lines such as SW620, K-562, MDA-MB-231, YES-4, T-98 and U251SP.

• Authors: Xiao Ren, Xinhua Lu, Aibing Ke, Zhihui Zheng, Jie Lin, Weili Hao, Jingtong Zhu, Yuling Fan, Yanbo Ding, Qin Jiang, Hua Zhang
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 64 Issue 4 Pg. 339-43 (Apr 2011) ISSN: 1881-1469 [Electronic] England
• PMID: 21285963 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthracyclines
• Anthraquinones
• Antineoplastic Agents
• N05WA963A
• N05WA963B
• N05WA963C
• N05WA963D

Topics

• Anthracyclines (chemistry, isolation & purification, pharmacology)
• Anthraquinones (chemistry, isolation & purification, pharmacology)
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
• Cell Proliferation (drug effects)
• Humans
• Neoplasms (drug therapy, pathology)
• Spectrum Analysis
• Streptomyces (metabolism)