Blood oxygen parameters in patients with chronic obstructive pulmonary disease. An evaluation of measured and calculated 2,3-diphosphoglycerate concentrations.
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| Abstract |
48 simultaneous arterial and venous blood samples from 15 patients with chronic obstructive pulmonary disease (COPD) were evaluated for calculated p50 and measured and calculated 2,3-diphosphoglycerate (DPG) concentration. 23 samples (48%) demonstrated a leftward shift in the calculated in vivo p50, whereas both measured and calculated DPG showed 5% below and 28% above reference range. Measured DPG was significantly higher than calculated DPG in the leftshifted group, whereas there was no significant difference in the non-leftshifted group. Mean arterial pH was alkalotic in the leftshifted group and significantly higher than mean pH in the non-leftshifted group. It is concluded that DPG concentration cannot be calculated by the algorithm in patients with COPD and a leftward shift in the oxygen dissociation curve.
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| Authors | C Nielsen, K B Hindsholm, E M Nielsen, B Dahl |
| Journal | Scandinavian journal of clinical and laboratory investigation. Supplementum (Scand J Clin Lab Invest Suppl) Vol. 203 Pg. 91-5 ( 1990) ISSN: 0085-591X [Print] Norway |
| PMID | 2128563 (Publication Type: Journal Article) |
| Chemical References |
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