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Nifedipine in the management of preterm labor: a systematic review and metaanalysis.

AbstractOBJECTIVE:
To determine the efficacy and safety of nifedipine as a tocolytic agent in women with preterm labor.
STUDY DESIGN:
A systematic review and metaanalysis of randomized controlled trials.
RESULTS:
Twenty-six trials (2179 women) were included. Nifedipine was associated with a significant reduction in the risk of delivery within 7 days of initiation of treatment and before 34 weeks' gestation, respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, neonatal jaundice, and admission to the neonatal intensive care unit when compared with β₂-adrenergic-receptor agonists. There was no difference between nifedipine and magnesium sulfate in tocolytic efficacy. Nifedipine was associated with significantly fewer maternal adverse events than β₂-adrenergic-receptor agonists and magnesium sulfate. Maintenance nifedipine tocolysis was ineffective in prolonging gestation or improving neonatal outcomes when compared with placebo or no treatment.
CONCLUSION:
AuthorsAgustín Conde-Agudelo, Roberto Romero, Juan Pedro Kusanovic
JournalAmerican journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 204 Issue 2 Pg. 134.e1-20 (Feb 2011) ISSN: 1097-6868 [Electronic] United States
PMID21284967 (Publication Type: Journal Article, Meta-Analysis, Research Support, N.I.H., Intramural, Review, Systematic Review)
CopyrightCopyright © 2011. Published by Mosby, Inc.
Chemical References
  • Adrenergic beta-2 Receptor Agonists
  • Tocolytic Agents
  • Magnesium Sulfate
  • Nifedipine
Topics
  • Adrenergic beta-2 Receptor Agonists (therapeutic use)
  • Female
  • Humans
  • Magnesium Sulfate (therapeutic use)
  • Nifedipine (therapeutic use)
  • Obstetric Labor, Premature (drug therapy)
  • Pregnancy
  • Randomized Controlled Trials as Topic
  • Tocolytic Agents (therapeutic use)
  • Treatment Outcome

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