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Dentin hypersensitivity reduction of a new toothpaste containing 8.0% arginine and 1450 ppm fluoride: an 8-week clinical study on Chinese adults.

AbstractPURPOSE:
To present the results of an 8-week dentin hypersensitivity clinical study in which the efficacy of a new Pro-Argin formula toothpaste, with gentle whitening benefits, containing 8.0% arginine, a high cleaning calcium carbonate system, and 1450 ppm fluoride as sodium monofluorophosphate (MFP) was compared to that of a commercial Pro-Argin formula toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride as MFP and a negative control toothpaste containing calcium carbonate and 1450 ppm fluoride as MFP.
METHODS:
An 8-week clinical study, with 121 subjects, was conducted in Chengdu, Sichuan, China, using a double-blind, stratified, three-treatment design. Tactile and air blast sensitivity assessments were used to compare the efficacy of the three products.
RESULTS:
This clinical study demonstrated that the new Pro-Argin formula toothpaste provided a significant reduction in dentin hypersensitivity when used over a period of 8 weeks. The study also showed that the new toothpaste provided significantly greater reductions (P < 0.05) in dentin hypersensitivity in response to tactile (64.4%, 71.1%, and 61.0%) and air blast (40.7%, 58.8%, and 74.4%) stimuli than the negative control toothpaste containing 1450 ppm fluoride after 2, 4, and 8 weeks of product use, respectively. The results for the new toothpaste did not differ significantly from those of the positive control toothpaste at all time points in the study.
AuthorsKehua Que, Yingying Fu, Lin Lin, Deyu Hu, Yun Po Zhang, Fotinos S Panagakos, William DeVizio, Luis R Mateo
JournalAmerican journal of dentistry (Am J Dent) Vol. 23 Spec No A Pg. 28A-35A (May 2010) ISSN: 0894-8275 [Print] United States
PMID21284249 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Dentin Desensitizing Agents
  • Phosphates
  • Tooth Bleaching Agents
  • Toothpastes
  • fluorophosphate
  • Arginine
  • Calcium Carbonate
  • Fluorides
Topics
  • Aged
  • Arginine (therapeutic use)
  • Calcium Carbonate (therapeutic use)
  • Dentin Desensitizing Agents (chemistry, therapeutic use)
  • Double-Blind Method
  • Female
  • Fluorides (therapeutic use)
  • Humans
  • Male
  • Middle Aged
  • Pain Measurement
  • Phosphates (therapeutic use)
  • Tooth Bleaching Agents
  • Toothpastes (chemistry, therapeutic use)
  • Touch

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