Abstract | PURPOSE: METHODS: An 8-week clinical study, with 121 subjects, was conducted in Chengdu, Sichuan, China, using a double-blind, stratified, three-treatment design. Tactile and air blast sensitivity assessments were used to compare the efficacy of the three products. RESULTS: This clinical study demonstrated that the new Pro-Argin formula toothpaste provided a significant reduction in dentin hypersensitivity when used over a period of 8 weeks. The study also showed that the new toothpaste provided significantly greater reductions (P < 0.05) in dentin hypersensitivity in response to tactile (64.4%, 71.1%, and 61.0%) and air blast (40.7%, 58.8%, and 74.4%) stimuli than the negative control toothpaste containing 1450 ppm fluoride after 2, 4, and 8 weeks of product use, respectively. The results for the new toothpaste did not differ significantly from those of the positive control toothpaste at all time points in the study.
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Authors | Kehua Que, Yingying Fu, Lin Lin, Deyu Hu, Yun Po Zhang, Fotinos S Panagakos, William DeVizio, Luis R Mateo |
Journal | American journal of dentistry
(Am J Dent)
Vol. 23 Spec No A
Pg. 28A-35A
(May 2010)
ISSN: 0894-8275 [Print] United States |
PMID | 21284249
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dentin Desensitizing Agents
- Phosphates
- Tooth Bleaching Agents
- Toothpastes
- fluorophosphate
- Arginine
- Calcium Carbonate
- Fluorides
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Topics |
- Aged
- Arginine
(therapeutic use)
- Calcium Carbonate
(therapeutic use)
- Dentin Desensitizing Agents
(chemistry, therapeutic use)
- Double-Blind Method
- Female
- Fluorides
(therapeutic use)
- Humans
- Male
- Middle Aged
- Pain Measurement
- Phosphates
(therapeutic use)
- Tooth Bleaching Agents
- Toothpastes
(chemistry, therapeutic use)
- Touch
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