Prognostic factors in patients with high-risk locally advanced salivary gland cancers treated with surgery and postoperative radiotherapy.

Abstract

BACKGROUND:

This study was designed to identify the factors associated with the outcome after standard treatment with surgery and postoperative radiotherapy (RT) for locally advanced salivary gland cancers.

METHODS:

We conducted a retrospective review of patients with salivary gland cancers registered in the University of Pittsburgh databases from 1990 to 2006.

RESULTS:

A total of 74 patients were analyzed. Histologic types included salivary duct carcinoma, 24%; adenoid cystic carcinoma, 23%; and adenocarcinoma, 19%; N2, 39%; N0-1, 58%; and major salivary gland origin, 80%. With a median follow-up of 4.1 years, the 5-year recurrence-free survival (RFS) was 49%, and the 5-year overall survival (OS) was 55%. The 5-year local RFS was 76% and the 5-year distant RFS was 60%. Using Cox-regression analysis, advanced N classification (N2) was the only significant predictor of both RFS and OS.

CONCLUSION:

The long-term survival of patients with high-risk, locally advanced salivary gland cancers is unsatisfactory. Advanced nodal disease is strongly associated with patient outcome and should be considered as a stratification factor in future trials in locally advanced salivary gland cancers.

• Authors: Trevor M Feinstein, Stephen Y Lai, Diana Lenzner, William Gooding, Robert L Ferris, Jennifer R Grandis, Eugene N Myers, Jonas T Johnson, Dwight E Heron, Athanassios Argiris
• Journal: Head & neck (Head Neck) Vol. 33 Issue 3 Pg. 318-23 (Mar 2011) ISSN: 1097-0347 [Electronic] United States
• PMID: 21284048 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Wiley Periodicals, Inc.

Topics

• Adult
• Aged
• Aged, 80 and over
• Cohort Studies
• Combined Modality Therapy
• Confidence Intervals
• Disease-Free Survival
• Female
• Humans
• Male
• Middle Aged
• Multivariate Analysis
• Neoplasm Invasiveness (pathology)
• Neoplasm Recurrence, Local (mortality, pathology, therapy)
• Neoplasm Staging
• Prognosis
• Proportional Hazards Models
• Radiotherapy, Adjuvant
• Retrospective Studies
• Risk Assessment
• Salivary Gland Neoplasms (mortality, pathology, radiotherapy, surgery)
• Survival Analysis
• Treatment Outcome
• Young Adult