Transoral laser microsurgery outcomes with early glottic cancer: the Dalhousie University experience.

Abstract

OBJECTIVE:

To report the results of transoral laser microsurgery for the treatment of early glottic cancer at our institution.

DESIGN:

Cohort study. Retrospective review of charts of patients diagnosed with tumour stage 1 or 2 (early stage; no nodes or metastases), previously untreated, primary glottic cancer, treated with transoral laser microsurgery at the Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada. The minimum follow-up period was two years.

SETTING:

Tertiary care head and neck cancer centre.

PARTICIPANTS:

Fifty-three patients treated between January 2002 and November 2007.

OUTCOME MEASURE:

Kaplan-Meier survival analysis for disease-free survival, overall survival and laryngectomy-free survival, at five years.

RESULTS:

The group comprised 46 men and seven women, with a mean age of 66 years (range 30-84 years). Mean follow up was 40 months (range 12-89 months). There were four cases of complications (7.5 per cent). Kaplan-Meier survival analysis revealed a five-year disease-free survival (including salvage) of 96.2 per cent, a five-year overall survival (all causes) of 88.8 per cent and a five-year laryngectomy-free survival of 98.1 per cent.

CONCLUSION:

Transoral laser microsurgery is a safe and effective initial treatment for early laryngeal cancer, and has high rates of laryngeal preservation and disease-free survival.

• Authors: S E Lester, M H Rigby, S M Taylor
• Journal: The Journal of laryngology and otology (J Laryngol Otol) Vol. 125 Issue 5 Pg. 509-12 (May 2011) ISSN: 1748-5460 [Electronic] England
• PMID: 21281534 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma (mortality, pathology, surgery)
• Cohort Studies
• Disease-Free Survival
• Female
• Glottis
• Humans
• Kaplan-Meier Estimate
• Laryngeal Neoplasms (mortality, pathology, surgery)
• Lasers, Gas
• Male
• Microsurgery (adverse effects, methods)
• Middle Aged
• Neoplasm Recurrence, Local (epidemiology)
• Neoplasms, Second Primary (epidemiology)
• Patient Preference
• Radiotherapy, Adjuvant
• Treatment Outcome
• Voice Quality