Abstract | BACKGROUND: AIMS: In the present study, we further describe AGR2 expression patterns all along the adult and fetal biliary tree and in cholangiocarcinomas. METHODS: RESULTS: In adult and fetal liver, the tall epithelial cells covering the large bile ducts as well as gallbladder epithelial cells showed strong AGR2 staining. Hilar and extrahepatic cholangiocarcinomas, and a subset of intrahepatic cholangiocarcinomas, which displayed a morphological mucus-excreting feature, also displayed AGR2 expression. In contrast, AGR2 expression was not detected in typical HCCs. CONCLUSION: Our study shows that the differential expression of AGR2 is a phenotypic feature of the cholangiocytes covering different segments of the biliary tree. This pattern of expression is conserved during fetal and adult life, as well as during biliary carcinogenesis.
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Authors | Sébastien Lepreux, Paulette Bioulac-Sage, Eric Chevet |
Journal | Liver international : official journal of the International Association for the Study of the Liver
(Liver Int)
Vol. 31
Issue 3
Pg. 322-8
(Mar 2011)
ISSN: 1478-3231 [Electronic] United States |
PMID | 21281432
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 John Wiley & Sons A/S. |
Chemical References |
- AGR2 protein, human
- Mucoproteins
- Oncogene Proteins
- Proteins
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Bile Duct Neoplasms
(metabolism, pathology)
- Bile Ducts, Intrahepatic
(embryology, metabolism, pathology)
- Carcinoma, Hepatocellular
(metabolism, pathology)
- Cholangiocarcinoma
(metabolism, pathology)
- Epithelial Cells
(metabolism)
- Female
- Fetal Development
(physiology)
- Fetus
(metabolism)
- Gallbladder
(embryology, metabolism)
- Gestational Age
- Humans
- Immunohistochemistry
- Liver
(embryology, metabolism, pathology)
- Liver Neoplasms
(metabolism, pathology)
- Male
- Middle Aged
- Mucoproteins
- Oncogene Proteins
- Proteins
(metabolism)
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