Probing and syringing with 3% solution of NaCl and/or 0.2 mg/ml mitomycin-C in nasolacrimal duct obstruction patients.

Abstract

OBJECTIVE:

To compare the efficacy of lacrimal probing and syringing among 3% solution of Sodium Chloride and/or 0.2 mg/ ml Mitomycin-C as an adjunctive medication.

DESIGN:

A prospective, randomized, 2 by 2 factorial design study.

MATERIAL AND METHOD:

Forty-eight of nasolacrimal duct obstruction patients with epiphora symptom were randomly assigned to receive either Normal Saline Solution or 3% solution of Sodium Chloride or 0.2 mg/ml Mitomycin-C solution or combined 3% solution of Sodium Chloride with 0.2 mg/ml Mitomycin-C solution, during office probing and syringing. The intervention was performed repeatedly at week 0, weeks 2 and 4. An assessment of epiphora with Visual Analogue Scale were evaluated at week 0, weeks 2, 4, 8 and 12.

RESULTS:

Probing and syringing was successfully reducing epiphora symptom. Mitomycin-C group showed a significant reduction in mean difference of Visual Analogue Scale score compared with Normal Saline Solution group (2.85, 95% CI: 1.164-4.536, p < 0.001) and 3% Sodium Chloride group (2.175, 95% CI: 0.489-3.861, p < 0.01). No complication or adverse event was found.

CONCLUSION:

0.2 mg/ml Mitomycin-C solution of was the most effective medication for office probing and syringing in reducing epiphora symptom in nasolacrimal duct obstruction patients.

• Authors: Raveewan Choontanom
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 93 Suppl 6 Pg. S197-202 (Nov 2010) ISSN: 0125-2208 [Print] Thailand
• PMID: 21280534 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Sodium Chloride
• Mitomycin

Topics

• Adult
• Aged
• Antibiotics, Antineoplastic (administration & dosage)
• Female
• Humans
• Lacrimal Duct Obstruction (therapy)
• Male
• Middle Aged
• Mitomycin (administration & dosage)
• Nasolacrimal Duct (surgery)
• Pain Measurement
• Prospective Studies
• Sodium Chloride (therapeutic use)
• Syringes
• Therapeutic Irrigation (methods)
• Treatment Outcome