The desensitizing efficacy of a novel stannous-containing sodium fluoride dentifrice: an 8-week randomized and controlled clinical trial.

Abstract

PURPOSE:

To assess the efficacy of a novel stannous-containing dentifrice in the reduction of dentin hypersensitivity when compared to a marketed positive control dentifrice.

METHODS:

An 8-week, single-center, randomized, parallel group, two-treatment, double-blind clinical study was conducted in a generally healthy adult population with moderate thermal and tactile dentin hypersensitivity. A total of 60 adults were enrolled into the study. Participants were stratified at baseline by age, gender, and cold air sensitivity scores, and randomly assigned to either an experimental stannous-containing sodium fluoride dentifrice or a marketed potassium nitrate positive control. Brushing was supervised on site after baseline and Week 4 examinations. All other product usage was unsupervised. Subjects brushed 2 minutes twice daily. At baseline, Week 4 and Week 8, efficacy outcomes were assessed for tactile sensitivity via the Yeaple Probe, and for thermal sensitivity with air-blast/SchiffAir Index.

RESULTS:

Fifty-eight subjects completed all evaluations. Both the experimental stannous-containing and positive control dentifrices provided significant (P< 0.05) reductions in both tactile and thermal dentin hypersensitivity compared to baseline at both Weeks 4 and 8. There were no significant differences in Yeaple Probe or Schiff Air Index results between the dentifrices with either efficacy measurement at Week 4 and Week 8 (P > or = 0.5375).

• Authors: Long Xing Ni, Tao He, Alice Chang, Lily Sun
• Journal: American journal of dentistry (Am J Dent) Vol. 23 Spec No B Pg. 17B-21B (Sep 2010) ISSN: 0894-8275 [Print] United States
• PMID: 21280422 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Cariostatic Agents
• Crest Pro-Health Dentifrice
• Dentifrices
• Dentin Desensitizing Agents
• Nitrates
• Phosphates
• Potassium Compounds
• Tin Compounds
• Tin Fluorides
• stannous chloride
• Sodium Fluoride
• potassium nitrate

Topics

• Adult
• Cariostatic Agents (therapeutic use)
• Dentifrices (chemistry, therapeutic use)
• Dentin Desensitizing Agents (therapeutic use)
• Dentin Sensitivity (prevention & control)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Nitrates (therapeutic use)
• Pain Measurement
• Phosphates (chemistry, therapeutic use)
• Potassium Compounds (therapeutic use)
• Sodium Fluoride (therapeutic use)
• Tin Compounds (therapeutic use)
• Tin Fluorides (chemistry, therapeutic use)
• Young Adult