Abstract | AIMS: Aloe has been a very popular folk remedy for inflammation-related pathological conditions despite the lack of studies reporting its efficacy in vivo. The present study evaluated the anti-inflammatory effects of aloe components ( aloin, aloesin and aloe-gel) known to be biologically active in the rat model of colitis. MAIN METHODS: KEY FINDINGS: Plasma leukotriene B(4) (LTB(4)) and tumor necrosis factor-α (TNF-α) concentrations were significantly decreased in all groups supplemented with aloe components compared to the colitis control group (p<0.05). Animals fed both a 0.1% and 0.5% aloesin supplemented diet showed colonic myeloperoxidase (MPO) activities which were decreased by 32.2% and 40.1%, respectively (p<0.05). Colonic mucosa TNF-α and interleukin-1ß (IL-1β) mRNA expressions were significantly reduced in all animals fed aloin, aloesin, or aloe-gel (p<0.05). SIGNIFICANCE: Dietary supplementation of aloe components ameliorates intestinal inflammatory responses in a DSS-induced ulcerative colitis rat model. In particular, aloesin was the most potent inhibitor. Further studies are required for a more complete understanding of the specific mechanism of the action of these supplements.
|
Authors | Mi-Young Park, Hoon-Jeong Kwon, Mi-Kyung Sung |
Journal | Life sciences
(Life Sci)
Vol. 88
Issue 11-12
Pg. 486-92
(Mar 14 2011)
ISSN: 1879-0631 [Electronic] Netherlands |
PMID | 21277867
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2011 Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Chromones
- Gels
- Glucosides
- Interleukin-1beta
- Plant Preparations
- Tumor Necrosis Factor-alpha
- Leukotriene B4
- Peroxidase
- Emodin
- alloin
- aloesin
|
Topics |
- Aloe
(chemistry)
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, therapeutic use)
- Chromones
(administration & dosage, therapeutic use)
- Colitis
(drug therapy, immunology, pathology)
- Colon
(drug effects, enzymology, immunology, pathology)
- Diet
- Dietary Supplements
- Disease Models, Animal
- Emodin
(administration & dosage, analogs & derivatives, therapeutic use)
- Gels
- Glucosides
(administration & dosage, therapeutic use)
- Interleukin-1beta
(immunology)
- Leukotriene B4
(blood)
- Male
- Peroxidase
(metabolism)
- Plant Preparations
(administration & dosage, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Tumor Necrosis Factor-alpha
(immunology)
|