HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Thalassemia and hemoglobinopathies in Southeast Asian newborns: diagnostic assessment using capillary electrophoresis system.

AbstractBACKGROUND:
We have investigated the Capillarys 2 Hemoglobin testing system to assist in presumptive diagnosis of thalassemia and hemoglobinopathies commonly found in Southeast Asia.
METHODS:
Study was conducted on 226 newborns. Hematological parameters were recorded and Hb profiles were examined on the Capillarys 2 Hemoglobin analyzer (SEBIA). DNA analyses were used to establish the final diagnoses.
RESULTS:
Among 226 newborns examined, 122 had thalassemias with 17 different genotypes. The capillary electrophoresis system could provide useful data for presumptive diagnoses of cases, especially those with Hb E and α-thalassemia. Hb E was found to be 2.6-6.2% in heterozygote whereas Hb Bart's were clearly observed in cases with compound heterozygous or homozygous α(+)-thalassemia and heterozygous α(0)-thalassemia. Hb H disease and other forms of α-thalassemia could be differentiated based on the presence of Hb Bart's and its percentage.
CONCLUSION:
The capillary electrophoresis system is applicable to newborn screening for common forms of thalassemia in Southeast Asia.
AuthorsHataichanok Srivorakun, Goonnapa Fucharoen, Yossombat Changtrakul, Patcharee Komwilaisak, Supan Fucharoen
JournalClinical biochemistry (Clin Biochem) Vol. 44 Issue 5-6 Pg. 406-11 (Apr 2011) ISSN: 1873-2933 [Electronic] United States
PMID21277293 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Topics
  • Asia, Southeastern
  • Electrophoresis, Capillary (methods)
  • Hemoglobinopathies (diagnosis, genetics)
  • Humans
  • Infant, Newborn
  • Neonatal Screening
  • Thalassemia (diagnosis, genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: