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Oncogenic osteomalacia of the cervical spine: a rare case of curative resection and reconstruction.

Abstract
Oncogenic osteomalacia (OO) is a rare paraneoplastic syndrome, with only 100 reported cases in the literature. The majority of OO-associated mesenchymal tumors are due to a lesion called phosphaturic mesenchymal tumor, mixed connective tissue (PMTMCT) variant. There have been only 6 reported cases of OO of the spine. With this paper the authors present a case of OO of the cervical spine in a patient who initially presented with multiple pathological fractures of unknown cause, and who eventually underwent staged C-5 spondylectomy followed by circumferential stabilization. Resection of the cervical lesion led to resolution of his hypophosphatemia and prevention of any further pathological fractures. The authors describe a rare cervical neoplasm, its treatment, and review the literature on this rare bony pathological entity.
AuthorsMurtaza Akhter, Patrick A Sugrue, Rick Bains, Yevgeniy A Khavkin
JournalJournal of neurosurgery. Spine (J Neurosurg Spine) Vol. 14 Issue 4 Pg. 453-6 (Apr 2011) ISSN: 1547-5646 [Electronic] United States
PMID21275557 (Publication Type: Case Reports, Journal Article)
Topics
  • Cervical Vertebrae (diagnostic imaging, surgery)
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Connective Tissue (diagnostic imaging, surgery)
  • Osteomalacia
  • Paraneoplastic Syndromes (diagnostic imaging, surgery)
  • Radiography
  • Spinal Neoplasms (diagnostic imaging, surgery)
  • Treatment Outcome

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