Abstract | OBJECTIVE: To investigate the diagnostic performance of combining the visual inspection with Lugol's iodine (VILI) and cytology screening to detect high-grade cervical intraepithelial neoplasia (CIN-2 or CIN-3) in symptomatic women, using histological examination as the standard reference test. STUDY DESIGN: Cross-sectional referral study utilizing secondary data from 538 medical records from a clinic specialized in cervical pathology in Brazil. RESULTS: Although the sensitivity reached 96.8%, the specificity was only 8.1%, with positive predictive value of 18.3% and negative predictive value of 92.3%. CONCLUSION: The combination of both tests proved to be highly sensitive, leading to a large decrease in the false negative results. This was achieved, however, at the cost of an excess in the rate of false positive results, thus making the combination unviable for screening in symptomatic women.
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Authors | Evandro Russo, Emil Kupek, Rita Maria Zanine |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 156
Issue 1
Pg. 91-5
(May 2011)
ISSN: 1872-7654 [Electronic] Ireland |
PMID | 21272990
(Publication Type: Evaluation Study, Journal Article)
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Copyright | Crown Copyright © 2011. Published by Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Coloring Agents
- Iodides
- Lugol's solution
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Topics |
- Adolescent
- Adult
- Aged
- Coloring Agents
- Cross-Sectional Studies
- Early Detection of Cancer
- False Positive Reactions
- Female
- Humans
- Iodides
- Medical Records
- Middle Aged
- Neoplasm Staging
- Risk Factors
- Sensitivity and Specificity
- Uterine Cervical Neoplasms
(diagnosis, epidemiology, pathology, physiopathology)
- Young Adult
- Uterine Cervical Dysplasia
(diagnosis, epidemiology, pathology, physiopathology)
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