Anti-arthritic activity of synthesized chondroitin sulfate E hexasaccharide.

Abstract	The purpose of this study was to investigate the anti-arthritic effects of synthesized chondroitin sulfate E hexasaccharide (sCSE-6, CAS 866407-73-0), using a type II collagen-induced arthritis model in mice. sCSE-6 was administered subcutaneously on a daily basis to type II collagen (CII)-sensitized mice from day 0 to day 55. The severity of arthritis, as well as the immunohistological features of the arthritic mice, were analyzed. sCSE-6 inhibited the course of arthritis and restored the body weight loss of CII-immunized mice. An immunohistological analysis showed that bone/cartilage destruction in the arthritic mice was significantly attenuated by sCSE-6 treatment, with a marginal inhibition of synovial inflammation also observed. The beneficial effect of sCSE-6 on bone destruction, which is the most important factor in preventing arthritis, is particularly noteworthy. In summary, sCSE-6 inhibited arthritis and helped to prevent bone and cartilage destruction in a type II collagen-induced arthritis model in mice. The findings indicated that CSE oligosaccharides might be a novel potential therapeutic tool for rheumatoid arthritis.
Authors	Taro Matsumoto, Tomoyuki Inoue, Akiko Takahashi, Akira Higuchi, Kayo Taniguchi-Morita, Masayuki Miyasaka, Jun-ichi Tamura
Journal	Arzneimittel-Forschung (Arzneimittelforschung) Vol. 60 Issue 12 Pg. 754-9 ( 2010) ISSN: 0004-4172 [Print] Germany
PMID	21265467 (Publication Type: Journal Article)
Chemical References	Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal chondroitin sulfate E hexasaccharide Dexamethasone Chondroitin Sulfates
Topics	Animals Anti-Inflammatory Agents (therapeutic use) Anti-Inflammatory Agents, Non-Steroidal (chemical synthesis, pharmacology) Arthritis, Experimental (drug therapy, pathology) Body Weight (drug effects) Carbohydrate Sequence Cartilage (pathology) Chondroitin Sulfates (chemical synthesis, pharmacology) Dexamethasone (therapeutic use) Hindlimb (pathology) Joints (pathology) Male Mass Spectrometry Mice Mice, Inbred DBA Molecular Sequence Data Mycobacterium Spectrometry, Mass, Electrospray Ionization

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