[The metabolic correction of erythrocyte function in patients with pulmonary tuberculosis complicated by pulmonary heart failure].

Abstract

In 80 patients with pulmonary tuberculosis aggravated by stage I-IIB cardiopulmonary insufficiency, the multimodality therapy included vektarion improving the ventilation/perfusion correlations (29 patients) and the combination of metabolic correctors (glutamevit and riboxin) (51 patients). The population analysis of peripheral blood erythrocytes (by the method of acidic erythrograms), the fractional composition of hemoglobin, the concentration of 2,3-diphosphoglycerine acid and the isozymic spectrum of LDH in erythrocytes served as methods of the treatment efficacy control. The treatment with vektarion noticeably reduced hypoxemia which was accompanied by positive shifts in erythrocyte metabolism and in the hemoglobin spectrum, producing but a negligible action on the population composition of erythrocytes. The combination of the metabolic correctors exerted a lesser effect on the fractional composition of hemoglobins, producing a well-defined positive action on erythrocyte function, decelerating the processes of their ageing. It is concluded that the highest positive effect may be produced by the combined use of all the three drugs bearing in mind their action mode.

• Authors: A G Khomenko, D G Kryzhanovskiĭ, G O Kaminskaia, B A Serebrianaia, N G Balta
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 62 Issue 9 Pg. 25-9 ( 1990) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Metabolicheskaia korrektsiia funktsional'nogo sostoianiia éritrotsitov u bol'nykh tuberkulezom legkikh, oslozhnennym legochno-serdechnoĭ nedostatochnost'iu.
• PMID: 2126395 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Diphosphoglyceric Acids
• 2,3-Diphosphoglycerate
• Carbon Dioxide
• Oxygen

Topics

• 2,3-Diphosphoglycerate
• Adult
• Aged
• Carbon Dioxide (blood)
• Chronic Disease
• Diphosphoglyceric Acids (blood)
• Drug Therapy, Combination
• Erythrocytes (drug effects, metabolism)
• Female
• Humans
• Male
• Middle Aged
• Oxygen (blood)
• Partial Pressure
• Pulmonary Heart Disease (blood, drug therapy, etiology)
• Tuberculosis, Pulmonary (blood, complications, drug therapy)