Abstract | OBJECTIVES: The aim of this pilot study was to assess post-treatment apparent diffusion coefficient (ADC) changes of diffuse large B-cell lymphoma lesions on respiratory-gated whole-body diffusion-weighted imaging (DWI), with integrated (18)F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (PET/CT) as the reference standard. MATERIALS AND METHODS: A total of 15 patients underwent both whole-body DWI (b = 50, 400, 800 s/mm(2)) and PET/CT before initiation and after 4 cycles of chemotherapy. ADC of residual masses (lymph node and organ lesions) was assessed both visually and quantitatively, including measurement of mean ADC (ADC).(Figure is included in full-text article.) RESULTS: After chemotherapy, among 85 examined lymph node regions, residual nodes were present in 62 (73%) regions on DWI. Of these 62 regions, 26 had persistent lymph nodes with longest transverse diameter >10 mm, ie, positive based on DWI size criteria. The mean ADC of these 26 regions increased from 0.658 × 10(-3) ± 0.153 mm(2)/s (standard deviation) at baseline to 1.501 × 10(-3) ± 0.307 mm(2)/s (paired t test, P < 0.0001). Only 6 of these 26 regions were considered positive on PET/CT. Combining visual ADC analysis to size criteria reduced the number of false-positive results of DWI from 20 to 2 regions. For organ involvement, ADC values also increased compared with baseline (1.558 × 10(-3) ± 0.424 mm(2)/s vs. 0.675 × 10(-3) ± 0.135 mm(2)/s, respectively; P = 0.0009). CONCLUSIONS:
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Authors | Chieh Lin, Emmanuel Itti, Alain Luciani, Benhalima Zegai, Shih-jui Lin, Frédérique Kuhnowski, Frédéric Pigneur, Isabelle Gaillard, Gaetano Paone, Michel Meignan, Corinne Haioun, Alain Rahmouni |
Journal | Investigative radiology
(Invest Radiol)
Vol. 46
Issue 5
Pg. 341-9
(May 2011)
ISSN: 1536-0210 [Electronic] United States |
PMID | 21263330
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Fluorodeoxyglucose F18
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Topics |
- Adult
- Aged
- Antineoplastic Agents
(therapeutic use)
- Diffusion Magnetic Resonance Imaging
(instrumentation, methods)
- Female
- Fluorodeoxyglucose F18
- Humans
- Lymphoma, Large B-Cell, Diffuse
(diagnosis, drug therapy, pathology)
- Male
- Middle Aged
- Pilot Projects
- Positron-Emission Tomography
- Prospective Studies
- Statistics, Nonparametric
- Time Factors
- Tomography, X-Ray Computed
- Young Adult
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