Abstract | BACKGROUND: Little is known about the contribution of bile and acid reflux to night-time symptoms generation in patients who failed PPI treatment. AIM: To compare the degree of night-time oesophageal acid and bile [by the surrogate duodenogastroesophageal reflux (DGER)] exposure between gastro-oesophageal reflux disease ( GERD) patients who failed and those who fully responded to PPI once a day while on treatment. METHODS:
Gastro-oesophageal reflux disease patients were assigned to the PPI failure group if they continued to report symptoms ≥3/week and to the PPI success group if they were asymptomatic for the last 3 months while on PPI once a day. All patients underwent upper endoscopy and subsequently simultaneous 24-h oesophageal Bilitec and pH testing while on PPI treatment. RESULTS: Twenty-three patients were enrolled into the PPI failure group and 24 patients into the PPI success group. The percentage of night-time pH<4 and the number of night-time acid reflux episodes were significantly higher in the PPI failure group as compared with the PPI success group. All night-time DGER parameters were similar between the PPI failure and PPI success groups. CONCLUSIONS: Night-time oesophageal acid exposure is significantly higher in the PPI failure group vs. PPI success group. The degree of night-time bile reflux is similar in the two groups of patients with GERD.
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Authors | T Hershcovici, L K Jha, H Cui, J Powers, R Fass |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 33
Issue 7
Pg. 837-44
(Apr 2011)
ISSN: 1365-2036 [Electronic] England |
PMID | 21261670
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2011 Blackwell Publishing Ltd. |
Chemical References |
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Topics |
- Adult
- Aged
- Bile
(physiology)
- Bile Reflux
(diagnosis)
- Circadian Rhythm
- Female
- Gastric Acid
(physiology)
- Gastroesophageal Reflux
(drug therapy)
- Humans
- Hydrogen-Ion Concentration
- Male
- Middle Aged
- Proton Pump Inhibitors
(therapeutic use)
- Statistics as Topic
- Stomach
(drug effects, physiology)
- Treatment Outcome
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