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Unexpected potentializing effect of a tacrine derivative (9-amino-7-methoxy-1,2,3,4 tetrahydroacridine) upon the non-epileptic myoclonus in baboons Papio papio.

Abstract
1. The influence of 7-methoxytacrine (7-MEOTA) on the non epileptic myoclonus of the Papio papio baboon was studied in 5 animals. 2. This type of myoclonus is thought to depend on a cholinergic system dysfunction since it can be induced by atropine and blocked by physostigmine. 3. 7-MEOTA, a tacrine derivative, is believed to display a conspicuous anticholinesterase activity but, surprisingly, it here potentiated the non epileptic myoclonus occuring either spontaneously or induced by atropine. 4. In baboons not spontaneously presenting the non epileptic myoclonus, 7-MEOTA induced the myoclonus in a fashion similar to atropine; such a myoclonus was blocked by physostigmine. 5. These data indicate a possible antagonist action of tacrine on the muscarinic acetylcholine receptor. From these data, it is suggested that caution is necessary when introducing a tacrine derivative in clinical practice.
AuthorsM Svejdová, I Rektor, C Silva-Barrat, C Menini
JournalProgress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry) Vol. 14 Issue 6 Pg. 961-6 ( 1990) ISSN: 0278-5846 [Print] England
PMID2126145 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Tacrine
  • 7-methoxytacrine
  • Atropine
  • Physostigmine
Topics
  • Animals
  • Atropine
  • Drug Synergism
  • Epilepsies, Myoclonic (chemically induced, physiopathology)
  • Myoclonus (chemically induced, drug therapy, physiopathology)
  • Papio
  • Physostigmine (therapeutic use)
  • Tacrine (analogs & derivatives, pharmacology)

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