Abstract | BACKGROUND: Key molecules in the T helper (Th)1 and Th2 pathways underlie differential responses to the progression and surgical treatment of cancer. We investigated the relationship between Th1/Th2 cytokine polymorphism and prognosis in patients with thoracic esophageal squamous cell cancer. MATERIALS AND METHODS: RESULTS:
IL-2 -330T>G genetic polymorphism was significantly associated with prognosis after esophagectomy. Univariate and multivariate analyses using a Cox proportional hazards model revealed that patients carrying the IL-2 -330G/G genotype had a significantly poorer prognosis than those carrying the T/G or T/T genotype. However, IL-2 -330T>G polymorphism was not associated with preoperative serum IL-2 levels. Moreover, interferon-γ, IL-12β, IL-4, and IL-10 genetic polymorphisms were not associated with prognosis after esophagectomy for thoracic esophageal squamous cell cancer. CONCLUSIONS:
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Authors | Satoru Motoyama, Masatomo Miura, Yudai Hinai, Kiyotomi Maruyama, Shuetsu Usami, Kei Yoshino, Toshinobu Nakatsu, Hajime Saito, Yoshihiro Minamiya, Jun-Ichi Ogawa |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 18
Issue 7
Pg. 1995-2002
(Jul 2011)
ISSN: 1534-4681 [Electronic] United States |
PMID | 21258967
(Publication Type: Journal Article)
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Chemical References |
- DNA, Neoplasm
- Interleukin-2
- Interleukin-10
- Interleukin-4
- Interferon-gamma
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
(genetics, secondary, surgery)
- DNA, Neoplasm
(blood, genetics)
- Esophageal Neoplasms
(genetics, pathology, surgery)
- Esophagectomy
- Female
- Follow-Up Studies
- Humans
- Interferon-gamma
(genetics)
- Interleukin-10
(genetics)
- Interleukin-2
(genetics)
- Interleukin-4
(genetics)
- Lymphatic Metastasis
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic
(genetics)
- Prognosis
- Survival Rate
- Th1 Cells
- Th2 Cells
- Thoracic Neoplasms
(genetics, pathology, surgery)
- Treatment Outcome
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