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Effects of zoledronic acid on healing of mandibular fractures: an experimental study in rabbits.

AbstractPURPOSE:
The purpose of the present study was to evaluate the effects of systemically administered zoledronic acid (ZA) on mandibular fracture healing in a rabbit model using radiodensitometric, biomechanical, histologic, and histomorphometric methods.
MATERIALS AND METHODS:
A total of 36 skeletally mature male New Zealand white rabbits were used. The rabbits were randomly divided into 2 groups. A mandibular corpus fracture was created experimentally in all 36 rabbits. The experimental group was administered an intravenous, single dose of 0.1 mg/kg ZA, and the control group was administered only saline infusion during the procedure. All rabbits were sacrificed on the 21st postoperative day. Digital radiodensitometric analysis, a 3-point bending test, and histologic and histomorphometric examinations were performed on the harvested hemimandibles. The data were analyzed statistically.
RESULTS:
Biomechanical testing data showed that ZA treatment resulted in a significant increase in the healed bone strength. This result was supported by the radiologic, histologic, and histomorphometric findings.
CONCLUSIONS:
The results of the present study have revealed that systemic administration of ZA accelerates and improves the bone healing of mandibular fractures.
AuthorsUfuk Tatli, Yakup Ustün, Mehmet Kürkçü, Ozgür Erdoğan, Cihan Cem Gürbüz, Hülya Ozgür, Sait Polat
JournalJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (J Oral Maxillofac Surg) Vol. 69 Issue 6 Pg. 1726-35 (Jun 2011) ISSN: 1531-5053 [Electronic] United States
PMID21256644 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Bone Density Conservation Agents
  • Diphosphonates
  • Imidazoles
  • Zoledronic Acid
Topics
  • Animals
  • Biomechanical Phenomena
  • Bone Density Conservation Agents (pharmacology)
  • Diphosphonates (pharmacology)
  • Fracture Healing (drug effects)
  • Imidazoles (pharmacology)
  • Male
  • Mandibular Fractures (pathology, physiopathology)
  • Rabbits
  • Zoledronic Acid

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