Abstract | PURPOSE: The purpose of the present study was to evaluate the effects of systemically administered zoledronic acid (ZA) on mandibular fracture healing in a rabbit model using radiodensitometric, biomechanical, histologic, and histomorphometric methods. MATERIALS AND METHODS: A total of 36 skeletally mature male New Zealand white rabbits were used. The rabbits were randomly divided into 2 groups. A mandibular corpus fracture was created experimentally in all 36 rabbits. The experimental group was administered an intravenous, single dose of 0.1 mg/kg ZA, and the control group was administered only saline infusion during the procedure. All rabbits were sacrificed on the 21st postoperative day. Digital radiodensitometric analysis, a 3-point bending test, and histologic and histomorphometric examinations were performed on the harvested hemimandibles. The data were analyzed statistically. RESULTS: Biomechanical testing data showed that ZA treatment resulted in a significant increase in the healed bone strength. This result was supported by the radiologic, histologic, and histomorphometric findings. CONCLUSIONS: The results of the present study have revealed that systemic administration of ZA accelerates and improves the bone healing of mandibular fractures.
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Authors | Ufuk Tatli, Yakup Ustün, Mehmet Kürkçü, Ozgür Erdoğan, Cihan Cem Gürbüz, Hülya Ozgür, Sait Polat |
Journal | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
(J Oral Maxillofac Surg)
Vol. 69
Issue 6
Pg. 1726-35
(Jun 2011)
ISSN: 1531-5053 [Electronic] United States |
PMID | 21256644
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
- Imidazoles
- Zoledronic Acid
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Topics |
- Animals
- Biomechanical Phenomena
- Bone Density Conservation Agents
(pharmacology)
- Diphosphonates
(pharmacology)
- Fracture Healing
(drug effects)
- Imidazoles
(pharmacology)
- Male
- Mandibular Fractures
(pathology, physiopathology)
- Rabbits
- Zoledronic Acid
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