Bile duct anastomotic stricture after adult-to-adult right lobe living donor liver transplantation.

Abstract

Duct-to-duct anastomosis (DDA) and hepaticojejunostomy (HJ) are options for biliary reconstruction in patients undergoing adult-to-adult right lobe living donor liver transplantation (ARLDLT), after which biliary anastomotic stricture (BAS) is common as a complication. The risk factors for BAS are not clearly defined. We aimed to determine the rate of post-ARLDLT BAS in our center and its associated factors. In 265 ARLDLT recipients, 55 (20.8%) developed postoperative BAS. The diagnosis was based on clinical, biochemical, histological, and radiological results. The BAS rates were 21.4% (43/201) for recipients undergoing DDA during transplantation, 18.9% (10/53) for recipients undergoing HJ, and 18.2% (2/11) for recipients undergoing both procedures. BAS and non-BAS patients had comparable demographics. The number of graft bile duct openings (P = 0.516) and the size of the graft's smallest bile duct (5 versus 5 mm, P = 0.4) were not significantly different between BAS and non-BAS patients. Univariate analysis showed that the factors associated with postoperative BAS were the recipient warm ischemia time (55 versus 51 minutes, P = 0.026), graft cold ischemia time (120 versus 108 minutes, P = 0.046), stent use (21.8% versus 7.1%, P = 0.001), postoperative acute cellular rejection (29.1% versus 11.0%, P = 0.001), and University of Wisconsin solution use (21.8% versus 7.1%, P = 0.001). Multivariate analysis showed that the cold ischemia time (odds ratio = 1.012, 95% confidence interval = 1.002-1.023, P = 0.014) and acute rejection (odds ratio = 3.180, 95% confidence interval = 1.606-6.853, P = 0.002) were significant factors. The graft survival rates of BAS and non-BAS patients were comparable. One patient required retransplantation for secondary biliary cirrhosis. In conclusion, BAS remains common after ARLDLT regardless of DDA or HJ. The graft cold ischemia time and postoperative acute cellular rejection are significantly associated with postoperative BAS.

• Authors: Kenneth Siu Ho Chok, See Ching Chan, Tan To Cheung, William Wei Sharr, Albert Chi Yan Chan, Chung Mau Lo, Sheung Tat Fan
• Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (Liver Transpl) Vol. 17 Issue 1 Pg. 47-52 (Jan 2011) ISSN: 1527-6473 [Electronic] United States
• PMID: 21254344 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 American Association for the Study of Liver Diseases.

Topics

• Acute Disease
• Adolescent
• Adult
• Aged
• Anastomosis, Surgical
• Bile Ducts (surgery)
• Chi-Square Distribution
• China
• Cholestasis (etiology)
• Cold Ischemia (adverse effects)
• Constriction, Pathologic
• Female
• Graft Rejection (etiology)
• Graft Survival
• Humans
• Kaplan-Meier Estimate
• Liver Transplantation (adverse effects)
• Living Donors
• Logistic Models
• Male
• Middle Aged
• Odds Ratio
• Retrospective Studies
• Risk Assessment
• Risk Factors
• Treatment Outcome
• Young Adult