Abstract | AIM: METHODS: Microscopical analyses on hematoxilin- eosin and immunohistochemistry reactions were performed to analyze the previously cited biological markers pattern in orofacial angiofibromas. RESULTS: Reactivity was observed for MMP-1, MMP-10 and TGF-β1, in addition to negative for TIMP-1 and α-SMA, except perivascular and epithelial staining for this. Concerning the intensity, a strong marking for MMP-1 in the basal layer of the epithelium, and a slight positivity in the suprabasal layers predominated. MMP-10 was slightly expressed in all epithelial layers. The connective tissue showed slight to moderate reactivity for MMP-1 and MMP-10. TIMP-1 demonstrated slight to moderate marking in the various layers of a single lesion and to TGF-β1 expression showed varied in intensity staining both between lesions and between tissue layers. CONCLUSION: MMP-1, MMP-10 and TGF-β1 exhibited reactivity in oral and cutaneous angiofibromas with heterogeneous distribution patterns among both tissue elements analyzed in the intensity of marking the same among the specimens. TIMP-1 showed reactivity predominantly negative in the specimens analyzed and α-SMA presented restricted to epithelial and perivascular regions of these lesions.
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Authors | L De Jesus Araújo, L Yamamoto De Almeida, J Santos Lima, H Martelli-Júnior, P R Ferreti Bonan |
Journal | Minerva stomatologica
(Minerva Stomatol)
2011 Jan-Feb
Vol. 60
Issue 1-2
Pg. 25-33
ISSN: 0026-4970 [Print] Italy |
PMID | 21252847
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ACTA2 protein, human
- Actins
- Biomarkers, Tumor
- Neoplasm Proteins
- Tissue Inhibitor of Metalloproteinase-1
- Transforming Growth Factor beta1
- MMP10 protein, human
- Matrix Metalloproteinase 10
- MMP1 protein, human
- Matrix Metalloproteinase 1
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Topics |
- Actins
(analysis)
- Adolescent
- Adult
- Aged
- Angiofibroma
(chemistry, genetics)
- Biomarkers, Tumor
(analysis)
- Child
- Epithelial Cells
(chemistry, ultrastructure)
- Facial Neoplasms
(chemistry, genetics)
- Female
- Fibroblasts
(chemistry, ultrastructure)
- Gingival Neoplasms
(chemistry, genetics)
- Humans
- Immunoenzyme Techniques
- Lip Neoplasms
(chemistry, genetics)
- Male
- Matrix Metalloproteinase 1
(analysis)
- Matrix Metalloproteinase 10
(analysis)
- Middle Aged
- Mouth Neoplasms
(chemistry, genetics)
- Neoplasm Proteins
(analysis)
- Neoplasms, Multiple Primary
(chemistry, genetics)
- Pericytes
(chemistry, ultrastructure)
- Skin Neoplasms
(chemistry, genetics)
- Tissue Inhibitor of Metalloproteinase-1
(analysis)
- Transforming Growth Factor beta1
(analysis)
- Tuberous Sclerosis
(metabolism)
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