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Glomerular basement membrane disorders in experimental models for renal diseases: impact on understanding pathogenesis and improving diagnosis.

Abstract
Animal models have provided important insights into human renal diseases that arise from mutations in genes that encode or regulate the synthesis of glomerular basement membrane proteins. This chapter describes several well-characterized animal models of type IV collagen disorders (Alport syndrome, HANAC syndrome), a laminin disorder (Pierson syndrome), nail-patella syndrome and HERNS syndrome. These models can be exploited in studies of the pathogenesis and treatment of such disorders.
AuthorsClifford E Kashtan, Yoav Segal
JournalContributions to nephrology (Contrib Nephrol) Vol. 169 Pg. 175-182 ( 2011) ISSN: 1662-2782 [Electronic] Switzerland
PMID21252518 (Publication Type: Journal Article)
CopyrightCopyright © 2011 S. Karger AG, Basel.
Chemical References
  • Collagen Type IV
  • Laminin
Topics
  • Abnormalities, Multiple (diagnosis, etiology, physiopathology)
  • Animals
  • Collagen Type IV (genetics, metabolism)
  • Disease Models, Animal
  • Dogs
  • Eye Abnormalities (diagnosis, etiology, physiopathology)
  • Glomerular Basement Membrane (physiopathology)
  • Humans
  • Kidney Diseases (diagnosis, etiology, physiopathology)
  • Laminin (genetics, metabolism)
  • Mice
  • Mutation (genetics)
  • Myasthenic Syndromes, Congenital
  • Nail-Patella Syndrome (diagnosis, etiology, physiopathology)
  • Nephritis, Hereditary (diagnosis, etiology, physiopathology)
  • Nephrotic Syndrome
  • Pupil Disorders (diagnosis, etiology, physiopathology)

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