Revaccination of children after completion of standard chemotherapy for acute lymphoblastic leukaemia: a pilot study comparing different schedules.

Abstract

Given that a significant proportion of children with acute lymphoblastic leukaemia (ALL) lose immune protection to tetanus, diphtheria, and poliomyelitis, revaccination is indicated after chemotherapy. Our randomized pilot study comparing different revaccination schedules suggests that children with ALL might be revaccinated with non-live vaccines as early as 3 months after chemotherapy.

• Authors: Thomas Lehrnbecher, Ralf Schubert, Regina Allwinn, Kader Dogan, Ulrike Koehl, Hans-Peter Grüttner
• Journal: British journal of haematology (Br J Haematol) Vol. 152 Issue 6 Pg. 754-7 (Mar 2011) ISSN: 1365-2141 [Electronic] England
• PMID: 21250973 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: © 2011 Blackwell Publishing Ltd.

Chemical References

• Antibodies, Bacterial
• Antibodies, Viral
• Diphtheria Toxoid
• Haemophilus Vaccines
• Haemophilus influenzae type b polysaccharide vaccine
• Immunoglobulins
• Poliovirus Vaccines
• Tetanus Toxoid
• Vaccines, Inactivated

Topics

• Adolescent
• Antibodies, Bacterial (biosynthesis)
• Antibodies, Viral (biosynthesis)
• Antineoplastic Combined Chemotherapy Protocols (pharmacology)
• Bacterial Capsules (administration & dosage, immunology)
• Child
• Child, Preschool
• Diphtheria Toxoid (administration & dosage, immunology)
• Female
• Haemophilus Vaccines (administration & dosage, immunology)
• Humans
• Immune Tolerance (drug effects)
• Immunization Schedule
• Immunization, Secondary (methods)
• Immunoglobulins (blood)
• Lymphocyte Subsets (drug effects, immunology)
• Male
• Pilot Projects
• Poliovirus Vaccines (administration & dosage, immunology)
• Precursor Cell Lymphoblastic Leukemia-Lymphoma (drug therapy, immunology)
• Tetanus Toxoid (administration & dosage, immunology)
• Vaccines, Inactivated (administration & dosage, immunology)
• Young Adult