SAPHO syndrome presenting as widespread bony metastatic disease of unknown origin.

Abstract

SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome represents an inflammatory spectrum ranging from an osteitis through to a spondyloarthropathy which may or may not be associated with dermatological manifestations. We present the case of a 52-year-old female who presented with non-specific back pain. Radiological imaging showed mixed lytic and sclerotic lesions of her lumbar spine and pelvis consistent with bony metastatic disease. She underwent CT-guided biopsy that confirmed histological findings in keeping with non-bacterial osteitis/chronic recurrent multifocal osteomyelitis. This case report and review of the literature highlights the importance of the SAPHO syndrome and its treatment.

• Authors: Bhupinder Mann, Daniel A Shaerf, Ahsan Sheeraz, John A Skinner, Asif Saifuddin
• Journal: Rheumatology international (Rheumatol Int) Vol. 32 Issue 2 Pg. 505-7 (Feb 2012) ISSN: 1437-160X [Electronic] Germany
• PMID: 21249499 (Publication Type: Case Reports, Journal Article)

Topics

• Acquired Hyperostosis Syndrome (complications, diagnosis)
• Bone Neoplasms (diagnosis, secondary)
• Diagnosis, Differential
• Discitis (diagnosis, etiology)
• Female
• Humans
• Middle Aged
• Osteomyelitis (diagnosis, etiology)