The role of G protein-coupled receptors in the pathology of Alzheimer's disease.

G protein-coupled receptors (GPCRs) are involved in numerous key neurotransmitter systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly influence the amyloid cascade through modulation of the α-, β- and γ-secretases, proteolysis of the amyloid precursor protein (APP), and regulation of amyloid-β degradation. Additionally, amyloid-β has been shown to perturb GPCR function. Emerging insights into the mechanistic link between GPCRs and AD highlight the potential of this class of receptors as a therapeutic target for AD.
AuthorsAmantha Thathiah, Bart De Strooper
JournalNature reviews. Neuroscience (Nat Rev Neurosci) Vol. 12 Issue 2 Pg. 73-87 (Feb 2011) ISSN: 1471-0048 [Electronic] England
PMID21248787 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Neurotransmitter Agents
  • Receptors, G-Protein-Coupled
  • Amyloid Precursor Protein Secretases
  • Alzheimer Disease (metabolism, pathology)
  • Amyloid Precursor Protein Secretases (metabolism)
  • Amyloid beta-Peptides (metabolism)
  • Amyloid beta-Protein Precursor (metabolism)
  • Animals
  • Brain (metabolism, pathology)
  • Humans
  • Neurotransmitter Agents (metabolism)
  • Receptors, G-Protein-Coupled (metabolism)

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