Persistence of a positive (1,3)-beta-D-glucan test after clearance of candidemia in hematopoietic stem cell transplant recipients.

Abstract

In 6 hematopoietic stem cell transplant (HSCT) recipients with candidemia, the (1,3)-β-d-glucan (BG) test was positive a median of 2.5 days after a positive blood culture. Only in 1 patient did BG positivity precede positive blood cultures. BG concentrations decreased in patients with clinical response, but positive BG results persisted long after blood cultures became sterile (median, 48 days).

• Authors: M Mikulska, E Furfaro, V Del Bono, F Gualandi, M T Van Lint, F Miletich, A Bacigalupo, C Viscoli
• Journal: Clinical and vaccine immunology : CVI (Clin Vaccine Immunol) Vol. 18 Issue 3 Pg. 518-9 (Mar 2011) ISSN: 1556-679X [Electronic] United States
• PMID: 21248156 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Proteoglycans
• beta-Glucans
• polysaccharide-K

Topics

• Adult
• Biomarkers (blood)
• Candida (isolation & purification)
• Candidemia (diagnosis, drug therapy)
• Female
• Hematopoietic Stem Cell Transplantation
• Humans
• Male
• Middle Aged
• Proteoglycans
• Time Factors
• beta-Glucans (blood)