Abstract |
The increased chemosensitivity of oligodendroglial tumours has been associated with loss of heterozygosity (LOH) of the p arm of chromosome 1 and the q arm of chromosome 19 (LOH 1p/19q). Other clinical and molecular factors have also been identified as being prognostic and predictive of treatment outcome. We reviewed 105 patients with oligodendroglioma treated at a single centre over 20 years. Median survival in oligodendroglioma patients with LOH 1p/19q was significantly longer (10.9 vs. 2.0 years). In the anaplastic oligodendroglioma group, univariate analysis demonstrated decreased patient age, presentation with seizures, use of adjuvant chemotherapy and LOH 1p/19q as predictors of improved survival. Multivariate analysis confirmed LOH 1p/19q as a significant predictor of improved survival (hazard ratio, 3.4; p=0.015). Median survival in patients with anaplastic oligodendroglioma with LOH 1p/19q was 15.4 years vs. 1.2 years for those without LOH 1p/19q. This study confirms the utility of LOH 1p/19q as a prognostic marker in oligodendroglioma.
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Authors | Jonathon F Parkinson, Vahid Afaghi, Cathy A Payne, Michael E Buckland, Janice M Brewer, Michael T Biggs, Nicholas S Little, Helen R Wheeler, Raymond J Cook, Kerrie L McDonald |
Journal | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
(J Clin Neurosci)
Vol. 18
Issue 3
Pg. 329-33
(Mar 2011)
ISSN: 1532-2653 [Electronic] Scotland |
PMID | 21247767
(Publication Type: Journal Article)
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Copyright | Copyright © 2010 Elsevier Ltd. All rights reserved. |
Chemical References |
- Tumor Suppressor Protein p53
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Topics |
- Adult
- Aged
- Brain Neoplasms
(genetics, mortality, pathology)
- Chemotherapy, Adjuvant
- Chromosomes, Human, Pair 1
(genetics)
- Chromosomes, Human, Pair 19
(genetics)
- Drug Resistance, Neoplasm
(genetics)
- Female
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Loss of Heterozygosity
- Male
- Middle Aged
- Oligodendroglioma
(genetics, mortality, pathology)
- Prognosis
- Proportional Hazards Models
- Tumor Suppressor Protein p53
(metabolism)
- Young Adult
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