Abstract | BACKGROUND: OBJECTIVE: METHODS: In this double-blind study, 30 subjects each had two seborrheic keratoses removed from their trunk or abdomen; one wound was treated with AHO and one with Poly/Bac twice daily. Clinical grading of wound healing and subjective irritation was assessed at days 7, 14, and 28 postwounding. Adverse events were recorded. RESULTS: Clinical grading assessment showed no differences between wounds treated with AHO versus Poly/Bac for erythema, edema, epithelial confluence, crusting, and scabbing at any time point. Subjective irritation assessment showed wounds treated with Poly/Bac had a significant increase in burning at week 1, whereas no differences were seen between treatments for stinging, itching, tightness, tingling, or pain. One case of allergic contact dermatitis was reported after Poly/Bac treatment. LIMITATIONS: This was a relatively small study. CONCLUSIONS:
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Authors | Zoe D Draelos, Ronald L Rizer, Nathan S Trookman |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 64
Issue 3 Suppl
Pg. S23-9
(Mar 2011)
ISSN: 1097-6787 [Electronic] United States |
PMID | 21247662
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study)
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Copyright | Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved. |
Chemical References |
- Ointments
- bacitracin, polymyxin B drug combination
- Bacitracin
- Petrolatum
- Polymyxin B
|
Topics |
- Bacitracin
(therapeutic use)
- Dermatitis, Allergic Contact
(etiology)
- Double-Blind Method
- Drug Resistance, Microbial
- Humans
- Keratosis, Seborrheic
(surgery)
- Ointments
(therapeutic use)
- Petrolatum
(therapeutic use)
- Polymyxin B
(therapeutic use)
- Skin Irritancy Tests
- Treatment Outcome
- Wound Healing
(drug effects)
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