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Silicon phthalocyanine (Pc 4) photodynamic therapy is a safe modality for cutaneous neoplasms: results of a phase 1 clinical trial.

AbstractBACKGROUND:
Photodynamic therapy (PDT) is a non-invasive treatment for non-melanoma skin cancer. However, PDT systems currently used clinically have limitations such as pain and superficial tissue penetration. The silicon phthalocyanine Pc 4 is a second-generation photosensitizer with peak absorption in the far red at 675 nm.
OBJECTIVE:
To assess the safety and tolerability of topically applied Pc 4 followed by red light (Pc 4-PDT) in treating cutaneous neoplasms.
STUDY DESIGN/MATERIALS AND METHODS:
Forty three adults with a diagnosis of neoplasms including actinic keratoses, Bowen's disease, squamous cell carcinoma, basal cell carcinoma, or mycosis fungoides were treated with a single administration of Pc 4-PDT and followed for 14 days. The study utilized a light and Pc 4 dose escalation design in sequential groups of three subjects each.
RESULTS:
Pc 4-PDT was well tolerated with no significant local toxicity or increased photosensitivity. It has promising biologic effects, particularly in mycosis fungoides where 14 of 35 subjects demonstrated a clinical response, which correlates with Pc 4-PDT-induced apoptosis, as measured by increased active caspase-3 in the treated skin lesions.
CONCLUSIONS:
Pc 4-PDT is a safe and tolerable treatment modality that effectively triggers apoptosis in cutaneous neoplasms such as mycosis fungoides.
AuthorsElma D Baron, Christi L Malbasa, Diana Santo-Domingo, Pingfu Fu, Janine D Miller, Kaija K Hanneman, Andrew H Hsia, Nancy L Oleinick, Valdir C Colussi, Kevin D Cooper
JournalLasers in surgery and medicine (Lasers Surg Med) Vol. 42 Issue 10 Pg. 728-35 (Dec 2010) ISSN: 1096-9101 [Electronic] United States
PMID21246576 (Publication Type: Clinical Trial, Phase I, Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2010 Wiley-Liss, Inc.
Chemical References
  • Indoles
  • Organosilicon Compounds
  • Photosensitizing Agents
  • silicon phthalocyanine
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma (drug therapy, pathology)
  • Cohort Studies
  • Female
  • Humans
  • Indoles (therapeutic use)
  • Male
  • Middle Aged
  • Organosilicon Compounds (therapeutic use)
  • Photochemotherapy
  • Photosensitizing Agents (therapeutic use)
  • Skin Neoplasms (drug therapy, pathology)
  • Treatment Outcome

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