Abstract | BACKGROUND: OBJECTIVE: To assess the safety and tolerability of topically applied Pc 4 followed by red light (Pc 4-PDT) in treating cutaneous neoplasms. STUDY DESIGN/MATERIALS AND METHODS: RESULTS: Pc 4-PDT was well tolerated with no significant local toxicity or increased photosensitivity. It has promising biologic effects, particularly in mycosis fungoides where 14 of 35 subjects demonstrated a clinical response, which correlates with Pc 4-PDT-induced apoptosis, as measured by increased active caspase-3 in the treated skin lesions. CONCLUSIONS: Pc 4-PDT is a safe and tolerable treatment modality that effectively triggers apoptosis in cutaneous neoplasms such as mycosis fungoides.
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Authors | Elma D Baron, Christi L Malbasa, Diana Santo-Domingo, Pingfu Fu, Janine D Miller, Kaija K Hanneman, Andrew H Hsia, Nancy L Oleinick, Valdir C Colussi, Kevin D Cooper |
Journal | Lasers in surgery and medicine
(Lasers Surg Med)
Vol. 42
Issue 10
Pg. 728-35
(Dec 2010)
ISSN: 1096-9101 [Electronic] United States |
PMID | 21246576
(Publication Type: Clinical Trial, Phase I, Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2010 Wiley-Liss, Inc. |
Chemical References |
- Indoles
- Organosilicon Compounds
- Photosensitizing Agents
- silicon phthalocyanine
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma
(drug therapy, pathology)
- Cohort Studies
- Female
- Humans
- Indoles
(therapeutic use)
- Male
- Middle Aged
- Organosilicon Compounds
(therapeutic use)
- Photochemotherapy
- Photosensitizing Agents
(therapeutic use)
- Skin Neoplasms
(drug therapy, pathology)
- Treatment Outcome
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