Image printing on the surface of anti-biofouling zwitterionic polymer brushes by ion beam irradiation.

Abstract

A CMB monomer was polymerized on a glass plate with a surface-confined ATRP initiator containing a 2-bromoisobutyryl group. The glass plate modified with a PCMB brush was highly hydrophilic and showed a strong resistance against non-specific adsorption of proteins and cell adhesion. Upon ion beam irradiation, furthermore, the PCMB brush was ablated and a hollow space with a designed shape could be made to which HEK293 cells (from human embryonic kidney) and Hep G2 (from human hepatoma) cells non-specifically adhered, while no adhesion of these cells to the non-treated area on the brush was observed. The present results clearly indicate the usefulness of ion beam-printed patterns of anti-biofouling zwitterionic polymer brushes in the biomedical field.

• Authors: Hiromi Kitano, Hisatomo Suzuki, Takuya Kondo, Kenta Sasaki, Shintaroh Iwanaga, Makoto Nakamura, Kohji Ohno, Yoshiyuki Saruwatari
• Journal: Macromolecular bioscience (Macromol Biosci) Vol. 11 Issue 4 Pg. 557-64 (Apr 08 2011) ISSN: 1616-5195 [Electronic] Germany
• PMID: 21243650 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Coated Materials, Biocompatible
• Ions
• Polymethacrylic Acids

Topics

• Cell Adhesion
• Coated Materials, Biocompatible (chemistry)
• HEK293 Cells
• Hep G2 Cells
• Humans
• Hydrophobic and Hydrophilic Interactions
• Ions
• Polymethacrylic Acids (chemistry)