Comparisons of clinical features of HLA-DRB1*07 positive and negative vitiligo patients in Chinese Han population.

Abstract

BACKGROUND:

Human leucocyte antigen (HLA)-II alleles have been found to be associated with vitiligo in different populations, and several studies also suggested that HLA class II alleles/haplotypes were associated with a different type vitiligo. Of HLA class II alleles, DRB1*07 has consistently shown a positive association with vitiligo in Chinese Han population.

OBJECTIVE:

To further explore the relationship between DRB1*07 and vitiligo and to evaluate the DRB1*07 effect on the clinical features of vitiligo in Chinese Han population.

METHODS:

This study investigated DRB1*07 allele distribution in 1178 unrelated Chinese vitiligo patients and 1743 healthy controls using polymerase chain reaction/sequence specific primer method and observed clinical differences between DRB1*07 positive and DRB1*07 negative patients.

RESULTS:

The analysis of the 1178 cases and 1743 controls revealed a highly association between DRB1*07 allele and vitiligo [odds ratio (OR) = 1.97, P = 2.13 × 10(-17) ]. DRB1*07 positive patients had early disease onset (OR = 1.49, P = 0.001), higher frequency of family history (OR = 1.44, P = 0.006) compared with DRB1*07 negative patients.

CONCLUSIONS:

The DRB1*07 showed significant association with vitiligo in the study population. This study confirmed that DRB1*07 positive patients had some obvious clinical differences from DRB1*07 negative patients in the Chinese Han population.

• Authors: D-Y Hu, Y-Q Ren, K-J Zhu, Y-M Lv, H Cheng, Z Zhang, Y Li, S-M He, J Tang, J-L Liu, Y Lin, Y-Y Sun, X-B Zuo, G Chen, L-D Sun, S Yang, X-J Zhang
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 25 Issue 11 Pg. 1299-303 (Nov 2011) ISSN: 1468-3083 [Electronic] England
• PMID: 21241376 (Publication Type: Comparative Study, Journal Article)
• Copyright: © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology.

Chemical References

• HLA-DRB1 Chains
• HLA-DRB1*07 antigen

Topics

• Alleles
• Case-Control Studies
• China
• Ethnicity
• HLA-DRB1 Chains (genetics, immunology)
• Humans
• Vitiligo (immunology, pathology)