Abstract | OBJECTIVE: METHODS: Three IRF5 single-nucleotide polymorphisms (rs729302, rs2004640, and rs2280714) were genotyped using TaqMan assays in 81 patients with systemic JIA (33 with MAS, 48 without) and 190 controls. RESULTS: There were no associations of the IRF5 gene polymorphisms or haplotypes under study with susceptibility to systemic JIA. There was a significant association of the rs2004640 T allele with MAS susceptibility (OR 4.11; 95% CI 1.84, 9.16; p = 0.001). The IRF5 haplotype (rs729302 A, rs2004640 T, and rs2280714 T), which was reported as conferring an increased risk of SLE, was significantly associated with MAS susceptibility in patients with systemic JIA (OR 4.61; 95% CI 1.73, 12.3; p < 0.001). CONCLUSION: IRF5 gene polymorphism is a genetic factor influencing susceptibility to MAS in patients with systemic JIA, and IRF5 contributes to the pathogenesis of MAS in these patients.
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Authors | Masakatsu Yanagimachi, Takuya Naruto, Takako Miyamae, Takuma Hara, Masako Kikuchi, Ryoki Hara, Tomoyuki Imagawa, Masaaki Mori, Hidenori Sato, Hiroaki Goto, Shumpei Yokota |
Journal | The Journal of rheumatology
(J Rheumatol)
Vol. 38
Issue 4
Pg. 769-74
(Apr 2011)
ISSN: 0315-162X [Print] Canada |
PMID | 21239750
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- IRF5 protein, human
- Interferon Regulatory Factors
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Topics |
- Adolescent
- Arthritis, Juvenile
(complications, genetics)
- Child
- Child, Preschool
- Female
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Interferon Regulatory Factors
(genetics)
- Kaplan-Meier Estimate
- Macrophage Activation Syndrome
(etiology, genetics)
- Male
- Polymorphism, Single Nucleotide
- Young Adult
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