Oral administration of ginsenoside Rh1 inhibits the development of atopic dermatitis-like skin lesions induced by oxazolone in hairless mice.

Abstract

In the present study, we examined the inhibitive effect of ginsenoside Rh1 on oxazolone-induced atopic dermatitis-like skin lesions in hairless mice. Oral administration of ginsenoside Rh1 improved clinical symptoms, and it was confirmed by histophathological analysis. In ginsenoside Rh1 (20mg/kg) group, ear swellings and ear weights were significantly lower than the control group. Moreover, elevation of IL-6 and total IgE levels in serum were suppressed by ginsenoside Rh1 (20mg/kg). In addition, ginsenoside Rh1 (20mg/kg) significantly increased mRNA expression of IFNγ and Foxp3, and slightly decreased IL-4 expression in draining lymph nodes. The results suggest that ginsenoside Rh1 can alleviate inflammatory symptoms in atopic dermatitis (AD) by reduction of IgE and IL-6 levels in peripheral blood, increase of Foxp3 expression in draining lymph nodes and suppression of inflammation in skin regions. Indeed, ginsenoside Rh1 exhibited therapeutic possibility in immune disorders.

• Authors: Hua Zheng, Yunju Jeong, Jeongmin Song, Geun Eog Ji
• Journal: International immunopharmacology (Int Immunopharmacol) Vol. 11 Issue 4 Pg. 511-8 (Apr 2011) ISSN: 1878-1705 [Electronic] Netherlands
• PMID: 21238621 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier B.V. All rights reserved.

Chemical References

• Forkhead Transcription Factors
• Foxp3 protein, mouse
• Ginsenosides
• Immunologic Factors
• Interleukin-6
• Oxazolone
• Immunoglobulin E
• ginsenoside Rh1
• Interferon-gamma

Topics

• Administration, Oral
• Animals
• Dermatitis, Atopic (immunology, pathology, prevention & control)
• Disease Models, Animal
• Forkhead Transcription Factors (biosynthesis, immunology)
• Ginsenosides (administration & dosage, therapeutic use)
• Immunoglobulin E (biosynthesis, blood, immunology)
• Immunologic Factors (administration & dosage, therapeutic use)
• Interferon-gamma (biosynthesis)
• Interleukin-6 (biosynthesis, blood, immunology)
• Lymph Nodes (immunology, metabolism)
• Mice
• Mice, Hairless
• Molecular Structure
• Oxazolone (immunology)
• Skin (drug effects, immunology, pathology)