Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1.

Abstract

We have evaluated the effects of the carbon monoxide-releasing molecule CORM-A1 [Na(2) (BH(3) CO(2) ); ALF421] on the development of relapsing-remitting experimental allergic encephalomyelitis (EAE) in SJL mice, an established model of multiple sclerosis (MS). The data show that the prolonged prophylactic administration of CORM-A1 improves the clinical and histopathological signs of EAE, as shown by a reduced cumulative score, shorter duration and a lower cumulative incidence of the disease as well as milder inflammatory infiltrations of the spinal cords. This study suggests that the use of CORM-A1 might represent a novel therapeutic strategy for the treatment of multiple sclerosis.

• Authors: P Fagone, K Mangano, C Quattrocchi, R Motterlini, R Di Marco, G Magro, N Penacho, C C Romao, F Nicoletti
• Journal: Clinical and experimental immunology (Clin Exp Immunol) Vol. 163 Issue 3 Pg. 368-74 (Mar 2011) ISSN: 1365-2249 [Electronic] England
• PMID: 21235533 (Publication Type: Journal Article)
• Copyright: © 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology.

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Boranes
• Carbonates
• Myelin Proteolipid Protein
• Peptide Fragments
• myelin proteolipid protein (139-151)
• sodium boranocarbonate
• Dexamethasone
• Carbon Monoxide

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, blood, pharmacology, therapeutic use)
• Body Weight (drug effects)
• Boranes (pharmacokinetics, therapeutic use)
• Carbon Monoxide (administration & dosage, blood, pharmacology, therapeutic use)
• Carbonates (pharmacokinetics, therapeutic use)
• Dexamethasone (pharmacology, therapeutic use)
• Encephalomyelitis, Autoimmune, Experimental (diagnosis, immunology, pathology, prevention & control)
• Female
• Mice
• Myelin Proteolipid Protein (immunology)
• Neutrophils (pathology)
• Peptide Fragments (immunology)
• Spinal Cord (drug effects, pathology)