The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder.

Abstract

The pathogenetic role of central serotonin transporters (SERT) in obsessive-compulsive disorder (OCD) has been investigated in vivo by positron emission tomography (PET) or single-photon emission computed tomography (SPECT) studies with inconsistent results. This might reflect methodological differences but possibly also the pathophysiological heterogeneity of the disorder, i.e. the age at onset of OCD. The aim of our study was to compare SERT availability in patients with OCD to healthy controls (HC) taking into account the onset type, other factors and covariates (e.g. SERT genotype, age, depression level, gender). We studied 19 drug-naive OCD patients (36±13 yr, eight females) with early onset (EO-OCD, n=6) or with late onset (LO-OCD, n=13), and 21 HC (38±8 yr, nine females) with PET and the SERT-selective radiotracer [11C]DASB. Statistical models indicated that a variety of covariates and their interaction influenced SERT availability measured by distribution volume ratios (DVR). These models revealed significant effects of onset type on DVR with lower values in LO-OCD (starting at age 18 yr) compared to EO-OCD and HC in limbic (e.g. the amygdala), paralimbic brain areas (the anterior cingulate cortex), the nucleus accumbens and striatal regions, as well as borderline significance in the thalamus and the hypothalamus. The putamen, nucleus accumbens and hypothalamus were found with significant interaction between two SERT gene polymorphisms (SERT-LPR and VNTR). These findings suggest that late but not early onset of OCD is associated with abnormally low SERT availability. In part, functional polymorphisms of the SERT gene might determine the differences.

• Authors: Swen Hesse, Katarina Stengler, Ralf Regenthal, Marianne Patt, Georg-Alexander Becker, Annegret Franke, Heike Knüpfer, Philipp M Meyer, Julia Luthardt, Ina Jahn, Donald Lobsien, Wolfgang Heinke, Peter Brust, Ulrich Hegerl, Osama Sabri
• Journal: The international journal of neuropsychopharmacology (Int J Neuropsychopharmacol) Vol. 14 Issue 5 Pg. 606-17 (Jun 2011) ISSN: 1469-5111 [Electronic] England
• PMID: 21232166 (Publication Type: Journal Article)

Chemical References

• Serotonin Plasma Membrane Transport Proteins

Topics

• Adult
• Aging
• Brain (diagnostic imaging, metabolism, physiopathology)
• Brain Mapping
• Cerebral Cortex (diagnostic imaging, pathology)
• Corpus Striatum (diagnostic imaging, pathology)
• Female
• Genotype
• Humans
• Hypothalamus (diagnostic imaging, pathology)
• Male
• Middle Aged
• Nucleus Accumbens (diagnostic imaging, pathology)
• Obsessive-Compulsive Disorder (diagnosis, genetics, metabolism)
• Polymorphism, Genetic
• Radionuclide Imaging
• Serotonin Plasma Membrane Transport Proteins (genetics, metabolism)
• Thalamus (diagnostic imaging, pathology)
• Time Factors
• Young Adult