HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Usefulness of late coronary thrombolysis (recombinant tissue-type plasminogen activator) in preserving left ventricular function in acute myocardial infarction.

Abstract
This study assesses whether administration of recombinant tissue-type plasminogen activator (rt-PA) up to 8 hours after onset of symptoms of acute myocardial infarction (AMI) may result in a significant improvement in left ventricular function. Sixty patients were classified into 3 groups: group A (n = 21) received rt-PA within 4 hours from symptom onset; the remaining 39 patients, admitted between 4 and 8 hours, were randomized into 2 groups--group B (n = 19) received rt-PA, and group C (n = 21) was treated with conventional therapy. Coronary and left ventricular angiograms were recorded 8 to 10 days after rt-PA administration. The patency rate of the infarct-related artery was 76% in group A, and 63 and 35% in group B and C, respectively. The Thrombolysis in Myocardial Infarction trial perfusion grade was higher in group A and B than in group C (A vs C: p less than 0.005; B vs C: p less than 0.01). Left ventricular ejection fraction was significantly higher in group A (60.2 +/- 10%) and B (54.7 +/- 12%) compared with group C (44.2 +/- 12%) (A vs C: p less than 0.01; B vs C: p less than 0.05). Regional wall motion of the entire ischemic zone was better in group A and B than in group C (A vs C: p less than 0.001; B vs C: p less than 0.01). In contrast, the kinesis of the central ischemic zone was significantly better in group A than in both group B and C (A vs B: p less than 0.05; A vs C: p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsB Villari, F Piscione, D Bonaduce, P Golino, T Lanzillo, M Condorelli, M Chiariello
JournalThe American journal of cardiology (Am J Cardiol) Vol. 66 Issue 19 Pg. 1281-6 (Dec 1 1990) ISSN: 0002-9149 [Print] UNITED STATES
PMID2123072 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Recombinant Proteins
  • Tissue Plasminogen Activator
Topics
  • Coronary Angiography
  • Hemodynamics (drug effects)
  • Humans
  • Middle Aged
  • Myocardial Infarction (drug therapy, physiopathology)
  • Recombinant Proteins (therapeutic use)
  • Stroke Volume (drug effects)
  • Thrombolytic Therapy
  • Tissue Plasminogen Activator (therapeutic use)
  • Vascular Patency (drug effects)
  • Ventricular Function, Left (drug effects, physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: